rs984971

This variant is located in the GCA gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

psoriasis

Zhang M et al. “Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.” Journal of Translational Medicine 23(1):133 (2025)
Allele A
OR 0.09
p 2.0e-15
N 472,819
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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The association between the IFIH1 locus and type 1 diabetes
AssociationN=1,767Qu HQ et al.(2008)· Diabetologia

This study validates the association between IFIH1 gene variants and type 1 diabetes in an independent cohort of 589 family trios (1,767 individuals) of mixed European descent. Using family-based association testing, the authors confirmed significant associations for rs2111485 (OR=0.84, p=0.0244) and rs984971 (OR=0.85, p=0.0455), replicating the previously reported IFIH1 locus findings. The results support the role of innate antivirus immunity in type 1 diabetes pathogenesis.

Traits studied:Type 1 diabetes
PubMedDOIMetascience Observatory

About GCA

This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

View all GCA variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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