rs9908998

This is a coding sequence variant variant in the LHX1-DT gene.

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Research that mentions this SNP (1)

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The association of lncRNA SNPs and SNPs‐environment interactions based on GWAS with HBV‐related HCC risk and progression
AssociationN=1,745Qing Liu et al.(2021)· Molecular Genetics & Genomic Medicine

This case-control study of 1,745 Southern Chinese subjects (643 HBV-related HCC patients, 549 CHB carriers, 553 HBV natural clearance subjects) identified 8 potentially functional lncRNA SNPs from two lncRNAs (lnc-ACACA-1 and lnc-RP11-150O12.3) located in HBV-related HCC GWAS susceptibility regions. The study found that rs9908998 in lnc-ACACA-1 significantly increased lymphatic metastasis risk (Adjusted OR = 1.95, 95% CI = 1.20-3.17), and that rs2275959, rs1008547, and rs11776545 in lnc-RP11-150O12.3 showed significant multiplicative and additive interactions with cancer family history on HBV-related HCC susceptibility, as well as associations with distant metastasis (Adjusted OR = 1.45, 95% CI = 1.06-1.97 for rs2275959; OR = 1.45, 95% CI = 1.06-1.98 for rs1008547; OR = 1.40, 95% CI = 1.03-1.91 for rs11776545).

Traits studied:Cancer embolusChronic hepatitis B (CHB)Distant metastasisHBV natural clearanceHepatitis B virus-related hepatocellular carcinoma (HBV-related HCC)Lymphatic metastasisTNM classification
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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