rs9925964

This is a splice region variant variant in the KAT8 gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

trait in response to warfarin

Asiimwe IG et al. “Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.” Blood Advances 8(20):5248-5261 (2024)
Allele G
OR 0.45
p 1.0e-15
N 1,504
Meta-analysis
multi-ancestry

body mass index

Hoffmann TJ et al. “A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.” Genetics 210(2):499-515 (2018)
Allele A
OR —
β 0.019
p 2.0e-13
N 334,487
Large GWAS
multi-ancestry
Winkler TW et al. “The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.” Plos Genetics 11(10):e1005378 (2015)
Allele A
OR —
β 0.020
p 7.0e-13
N 309,889
Large GWAS
European
Locke AE et al. “Genetic studies of body mass index yield new insights for obesity biology.” Nature 518(7538):197-206 (2015)
Allele A
OR 0.02
p 9.0e-11
N 238,944
Large GWAS
multi-ancestry

smoking behavior, body mass index

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele A
OR 0.02
p 5.0e-8
N 196,760
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Influence of genetic variants associated with body mass index on eating behavior in childhood
AssociationN=3,179Claire Monnereau et al.(2017)· Obesity

In a population-based cohort of 3,179 children, the study tested two weighted genetic risk scores based on 15 childhood and 97 adult BMI-associated SNPs, plus ten individual appetite/satiety SNPs, for association with eating behavior measures. The 97 SNP adult BMI risk score was nominally associated with lower satiety responsiveness (β: -0.007 SD, 95% CI -0.013, 0.000), while individual SNPs rs11030104 (BDNF) and rs10733682 (LMX1B) showed nominal associations with reduced satiety responsiveness (β: -0.057 to -0.087 SD). Overall, findings do not strongly support that BMI-associated SNPs influence eating behavior at this young age.

Traits studied:Body mass index (BMI)Enjoyment of foodFood fussinessFood responsivenessSatiety responsivenessSlowness in eating
PubMedDOIMetascience Observatory

About KAT8

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

View all KAT8 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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