rs9936833
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Barrett's esophagus
Su Z et al. “Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.” Nature Genetics 44(10):1131-6 (2012)
Allele C
OR 1.14
p 3.0e-10
N 7,024
Large GWAS
European
▶Research that mentions this SNP (1)
▶Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma riskAssociationN=1,036Polat Dura et al.(2013)· International Journal of Cancer
Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk
AssociationN=1,036Polat Dura et al.(2013)· International Journal of Cancer
This Dutch case-control study (431 esophageal cancer patients, 605 controls) examined whether Barrett's esophagus-associated variants also increase esophageal cancer risk. MHC rs9257809 G allele increased esophageal squamous cell carcinoma (ESCC) risk (OR 1.76, 95% CI 1.16-2.66), while FOXF1 rs9936833 C allele increased esophageal adenocarcinoma (EAC) risk (OR 1.21, 95% CI 0.99-1.47).
Traits studied:Barrett's esophagusEsophageal adenocarcinomaEsophageal squamous cell carcinoma
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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