rs9987109
This variant is located in the NAT2 gene.
▶Research that mentions this SNP (1)
▶Impact of interactions of cigarette smoking with NAT2 polymorphisms on rheumatoid arthritis risk in African AmericansAssociationN=995Mikuls TR et al.(2012)· Arthritis & Rheumatism
This case-control study examined gene-environment interactions between smoking and drug-metabolizing enzyme (DME) polymorphisms in rheumatoid arthritis (RA) risk among 727 African American RA cases and 268 controls. While no individual DME genotypes were significantly associated with RA, significant additive interactions were found between heavy smoking (≥10 pack-years) and NAT2 SNPs rs9987109 (P_add=0.000003) and rs1208 (P_add=0.00001), with attributable proportions ranging from 0.61-0.67. The NAT2 rs1208 haplotype was associated with a 4.15-fold increased RA risk in heavy smokers (p=0.005).
About NAT2
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2). [provided by RefSeq, Sep 2019]
View all NAT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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