Trait
SNPs associated with Neural tube defects
6 genetic variants across 5 genes have been associated with Neural tube defects in published research. Key genes include MCM6, MTHFR, MTR.
Associated variants6 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1801133 | MTHFR | Increased neural tube defect risk in offspring | Meta-analysis |
| rs1802059 | MTRR | Increased maternal risk for neural tube defect-affected pregnancies | Meta-analysis |
| rs1805087 | MTR | Altered neural tube defect susceptibility | Meta-analysis |
| rs1801394 | MTRR | Increased neural tube defect risk in Asian populations | Candidate gene study |
| rs1979277 | SHMT1 | Increased neural tube defect risk | Preliminary work |
| rs4988235 | MCM6 | Increased offspring neural tube defect risk in non-Hispanic White mothers | Preliminary work |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.