ACP3
acid phosphatase 3
Summary
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
Known Variants25 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs141502063 | 3:132,036,310 | G/A | — | uncertain significance |
| rs150403414 | 3:132,036,325 | G/A | — | uncertain significance |
| rs138177825 | 3:132,036,371 | T/C | — | uncertain significance |
| rs1576410208 | 3:132,047,107 | T/C | — | likely benign |
| rs768803310 | 3:132,047,138 | A/G | — | uncertain significance |
| rs370760828 | 3:132,047,168 | G/C | — | uncertain significance |
| rs981688826 | 3:132,047,204 | C/G | — | uncertain significance |
| rs780865621 | 3:132,050,522 | A/G | — | uncertain significance |
| rs561832892 | 3:132,050,528 | T/C | — | uncertain significance |
| rs368005227 | 3:132,051,063 | C/T | — | uncertain significance |
| rs745636621 | 3:132,051,064 | G/A | — | uncertain significance |
| rs1937412778 | 3:132,051,082 | T/C | — | uncertain significance |
| rs144823139 | 3:132,051,116 | T/C | — | benign |
| rs2529271751 | 3:132,056,318 | A/G | — | uncertain significance |
| rs930064679 | 3:132,056,339 | G/A | — | uncertain significance |
| rs145309744 | 3:132,056,362 | A/G | — | likely benign |
| rs141708902 | 3:132,063,792 | C/A | — | uncertain significance |
| rs1182891594 | 3:132,063,893 | G/C | — | uncertain significance |
| rs17241868 | 3:132,066,160 | A/G | regulatory region variant | — |
| rs1269179298 | 3:132,068,800 | G/C | — | uncertain significance |
| rs116804987 | 3:132,071,602 | T/G | — | benign |
| rs369601255 | 3:132,071,630 | G/A | — | uncertain significance |
| rs770158263 | 3:132,075,555 | C/T | — | uncertain significance |
| rs148218296 | 3:132,075,565 | C/A | — | uncertain significance |
| rs151032097 | 3:132,075,676 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.