rs17241868
This is a regulatory region variant variant in the ACP3 gene.
▶Research that mentions this SNP (1)
▶Genome-wide genotype-based risk model for survival in core binding factor acute myeloid leukemia patientsAssociationN=104Silvia Park et al.(2018)· Annals of Hematology
This genome-wide SNP association study in 104 core binding factor acute myeloid leukemia (CBF-AML) patients developed predictive risk models for overall survival (OS) and event-free survival (EFS) incorporating six SNPs each combined with clinical factors. The OS model significantly stratified patients into low- and high-risk groups with 3-year survival rates of 80.4% vs 22.0% (p=8.75×10⁻¹³), while the EFS model achieved 75.0% vs 17.1% (p=5.95×10⁻¹³), demonstrating that genome-wide SNP genotyping can improve survival prediction in CBF-AML beyond conventional clinical factors.
About ACP3
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
View all ACP3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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