ADAM10

ADAM metallopeptidase domain 10

Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

Known Variants68 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs376138084	15:58,889,751	G/A	—	uncertain significance
rs1210549488	15:58,889,787	G/A	—	uncertain significance
rs151017836	15:58,889,793	G/A	—	uncertain significance
rs2548805029	15:58,889,807	A/G	—	uncertain significance
rs144826830	15:58,891,906	T/C	—	benign
rs2548806094	15:58,891,923	C/T	—	uncertain significance
rs75112899	15:58,892,098	T/A	—	benign
rs756896693	15:58,902,531	G/A	—	uncertain significance
rs2548810034	15:58,902,639	G/A	—	uncertain significance
rs757667202	15:58,902,716	A/G	—	uncertain significance
rs12439189	15:58,902,769	C/A	—	benign
rs2305421	15:58,903,083	A/G	regulatory region variant	benign
rs2548810573	15:58,903,255	C/G	—	uncertain significance
rs370531306	15:58,903,267	C/T	—	uncertain significance
rs547185865	15:58,903,289	G/C	—	uncertain significance
rs199764041	15:58,903,291	T/C	—	uncertain significance
rs200668426	15:58,904,011	T/C	—	uncertain significance
rs1411854812	15:58,904,053	G/T	—	uncertain significance
rs483352916	15:58,904,131	C/T	missense variant	pathogenic
rs8039791	15:58,904,237	C/T	—	benign
rs116923065	15:58,913,643	T/A	—	benign
rs113236681	15:58,913,663	A/G	—	benign
rs483352913	15:58,913,670	C/T	missense variant	pathogenic
rs766141745	15:58,913,712	G/A	—	uncertain significance
rs2548815288	15:58,913,772	T/C	—	uncertain significance
rs12899638	15:58,920,275	G/A	—	benign
rs12900643	15:58,920,363	T/C	—	benign
rs74018920	15:58,925,088	A/G	—	benign
rs2548820510	15:58,925,484	T/C	—	uncertain significance
rs183295010	15:58,925,566	A/G	—	benign
rs7175610	15:58,925,756	G/C	—	benign
rs7165402	15:58,932,932	T/C	—	benign
rs35731698	15:58,933,027	G/T	—	benign
rs2548824179	15:58,933,142	A/T	—	uncertain significance
rs184219637	15:58,934,745	T/C	intron variant	—
rs2303532	15:58,935,986	T/C	—	benign
rs201482030	15:58,938,357	T/C	—	uncertain significance
rs140094923	15:58,938,399	G/T	—	uncertain significance
rs12912286	15:58,938,436	T/C	—	benign
rs772986976	15:58,957,320	C/A	—	uncertain significance
rs145518263	15:58,957,340	T/C	missense variant	risk factor
rs61751103	15:58,957,371	C/G	missense variant	risk factor
rs758796553	15:58,957,379	C/T	—	likely benign
rs74787954	15:58,957,475	T/C	—	benign
rs2548842323	15:58,971,352	T/G	—	uncertain significance
rs149887824	15:58,971,362	G/A	—	benign
rs483352914	15:58,971,378	A/T	stop gained	pathogenic
rs483352912	15:58,971,392	G/A	missense variant	pathogenic
rs144890810	15:58,971,448	A/G	—	conflicting classifications of pathogenicity
rs111517153	15:58,971,491	A/G	—	likely benign
rs201590398	15:58,974,438	T/A	—	likely benign
rs2140755160	15:58,974,481	G/A	—	uncertain significance
rs149020434	15:58,974,512	G/A	—	uncertain significance
rs4774310	15:58,985,164	T/G	intron variant	—
rs12911832	15:58,985,904	A/T	intron variant	—
rs347117	15:59,000,957	C/T	upstream gene variant	—
rs1898704698	15:59,009,788	T/G	—	uncertain significance
rs374249563	15:59,009,826	T/C	—	likely benign
rs1167161957	15:59,009,926	C/A	—	uncertain significance
rs6494034	15:59,010,111	C/G	—	benign
rs383902	15:59,034,174	C/T	intron variant	—
rs1347493623	15:59,041,669	C/A	—	likely benign
rs938974829	15:59,041,704	G/A	—	likely benign
rs753995003	15:59,041,714	A/G	—	uncertain significance
rs653765	15:59,042,012	T/C	regulatory region variant	benign
rs881117	15:59,042,143	G/T	—	benign
rs514049	15:59,042,363	C/A	regulatory region variant	benign
rs2414609	15:59,042,452	G/A	—	benign

Gene information from NCBI Gene. Variant classifications from ClinVar.