ADAM15
ADAM metallopeptidase domain 15
Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Known Variants73 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs778358417 | 1:155,023,867 | G/C | — | uncertain significance |
| rs2526189513 | 1:155,023,872 | G/A | — | uncertain significance |
| rs975789318 | 1:155,023,915 | T/C | — | uncertain significance |
| rs769883732 | 1:155,023,917 | C/T | — | uncertain significance |
| rs923952573 | 1:155,023,939 | T/A | — | uncertain significance |
| rs752464548 | 1:155,025,191 | G/A | — | uncertain significance |
| rs1253515134 | 1:155,025,242 | A/G | — | likely benign |
| rs546412888 | 1:155,025,944 | C/T | — | uncertain significance |
| rs758281032 | 1:155,026,439 | G/A | — | uncertain significance |
| rs372677722 | 1:155,026,454 | G/A | — | uncertain significance |
| rs769281758 | 1:155,026,800 | G/A | — | likely benign |
| rs2526254956 | 1:155,026,828 | T/C | — | uncertain significance |
| rs775508564 | 1:155,026,836 | G/A | — | uncertain significance |
| rs766437810 | 1:155,026,920 | C/T | — | uncertain significance |
| rs201298826 | 1:155,026,947 | C/G | — | uncertain significance |
| rs745498420 | 1:155,026,968 | C/T | — | uncertain significance |
| rs569036944 | 1:155,027,219 | A/C | — | — |
| rs2526279587 | 1:155,028,315 | C/A | — | uncertain significance |
| rs373813408 | 1:155,028,418 | A/C | — | uncertain significance |
| rs753684580 | 1:155,028,421 | G/C | — | likely benign |
| rs77062647 | 1:155,028,450 | C/A | — | benign |
| rs200886586 | 1:155,028,562 | C/T | — | uncertain significance |
| rs199836198 | 1:155,028,614 | G/A | — | likely benign |
| rs2526286008 | 1:155,028,634 | C/T | — | likely benign |
| rs2526287054 | 1:155,028,701 | C/T | — | uncertain significance |
| rs776868921 | 1:155,028,944 | A/G | — | uncertain significance |
| rs2102405216 | 1:155,029,435 | T/C | — | uncertain significance |
| rs768018320 | 1:155,029,465 | A/G | — | uncertain significance |
| rs753271272 | 1:155,029,468 | G/T | — | uncertain significance |
| rs372199497 | 1:155,029,681 | A/C | — | uncertain significance |
| rs141787686 | 1:155,029,702 | G/A | — | likely benign |
| rs758158795 | 1:155,029,719 | C/A | — | uncertain significance |
| rs1258171122 | 1:155,029,732 | T/A | — | uncertain significance |
| rs754878868 | 1:155,029,749 | G/A | — | uncertain significance |
| rs116408150 | 1:155,029,770 | C/A | — | uncertain significance |
| rs1661902314 | 1:155,029,785 | T/C | — | uncertain significance |
| rs762419785 | 1:155,029,794 | A/G | — | uncertain significance |
| rs192733958 | 1:155,029,808 | G/A | — | likely benign |
| rs752402268 | 1:155,029,812 | G/A | — | uncertain significance |
| rs561749242 | 1:155,030,334 | C/T | — | uncertain significance |
| rs114498585 | 1:155,030,364 | G/A | missense variant | — |
| rs754550443 | 1:155,030,472 | A/G | — | uncertain significance |
| rs749202910 | 1:155,030,499 | A/G | — | uncertain significance |
| rs149542900 | 1:155,030,534 | G/A | — | uncertain significance |
| rs148719743 | 1:155,030,538 | C/T | — | uncertain significance |
| rs149853516 | 1:155,030,599 | C/A | missense variant | — |
| rs368562955 | 1:155,030,786 | C/T | — | uncertain significance |
| rs759981258 | 1:155,030,787 | G/A | — | likely benign |
| rs776120235 | 1:155,030,808 | T/C | — | uncertain significance |
| rs1030944811 | 1:155,030,811 | A/T | — | uncertain significance |
| rs765065831 | 1:155,030,836 | C/T | — | likely benign |
| rs2526326948 | 1:155,030,874 | A/C | — | uncertain significance |
| rs192799127 | 1:155,031,180 | G/T | — | benign |
| rs753923130 | 1:155,031,202 | G/A | — | likely benign |
| rs2526356742 | 1:155,032,381 | T/C | — | uncertain significance |
| rs959879235 | 1:155,032,405 | T/C | — | uncertain significance |
| rs370807772 | 1:155,032,436 | C/T | — | uncertain significance |
| rs766608364 | 1:155,032,441 | C/A | — | uncertain significance |
| rs114710302 | 1:155,032,765 | G/A | — | uncertain significance |
| rs761101051 | 1:155,032,783 | G/A | — | uncertain significance |
| rs139427980 | 1:155,032,818 | A/C | — | likely benign |
| rs144472956 | 1:155,033,243 | G/C | — | uncertain significance |
| rs776967181 | 1:155,033,277 | C/T | — | uncertain significance |
| rs146997186 | 1:155,033,297 | C/G | — | uncertain significance |
| rs138833444 | 1:155,033,913 | C/T | — | uncertain significance |
| rs483352774 | 1:155,033,920 | C/T | — | uncertain significance |
| rs199706846 | 1:155,033,921 | C/A | — | uncertain significance |
| rs146141248 | 1:155,033,922 | C/A | — | uncertain significance |
| rs1041685889 | 1:155,033,934 | T/C | — | uncertain significance |
| rs530220807 | 1:155,033,948 | G/A | — | uncertain significance |
| rs568276581 | 1:155,034,414 | G/A | — | uncertain significance |
| rs772799464 | 1:155,034,432 | C/T | — | uncertain significance |
| rs1018507938 | 1:155,034,803 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.