Trait
SNPs associated with HbA1c
1362 genetic variants across 308 genes have been associated with HbA1c in published research. Key genes include A4GALT, ABCB11, ABCC1.
Associated variants1,362 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs1050828 | G6PD | GWAS association (p=7.0e-322) | Meta-analysis |
| rs1800562 | HFE | GWAS association (p=1.0e-240) | Meta-analysis |
| rs2408955 | — | GWAS association (p=3.0e-212) | Meta-analysis |
| rs10830963 | MTNR1B | GWAS association (p=3.0e-177) | Meta-analysis |
| rs11558471 | SLC30A8 | GWAS association (p=1.0e-131) | Meta-analysis |
| rs560887 | G6PC2 | GWAS association (p=6.0e-122) | Meta-analysis |
| rs11708067 | ADCY5 | GWAS association (p=1.0e-118) | Meta-analysis |
| rs2748427 | TMC6 | GWAS association (p=9.0e-70) | Meta-analysis |
| rs4745982 | — | GWAS association (p=3.0e-65) | Meta-analysis |
| rs1046896 | FN3KRP | GWAS association (p=4.0e-64) | Meta-analysis |
| rs4737009 | ANK1 | GWAS association (p=8.0e-56) | Meta-analysis |
| rs10823343 | — | GWAS association (p=2.0e-55) | Meta-analysis |
| rs837763 | — | GWAS association (p=5.0e-38) | Meta-analysis |
| rs4607517 | — | GWAS association (p=9.0e-38) | Meta-analysis |
| rs3824065 | YKT6 | GWAS association (p=4.0e-35) | Meta-analysis |
| rs13134327 | — | GWAS association (p=3.0e-26) | Meta-analysis |
| rs857691 | SPTA1 | GWAS association (p=4.0e-25) | Meta-analysis |
| rs198846 | H1-6 | GWAS association (p=1.0e-23) | Meta-analysis |
| rs592423 | — | GWAS association (p=2.0e-23) | Meta-analysis |
| rs11603334 | ARAP1 | GWAS association (p=1.0e-22) | Meta-analysis |
| rs4820268 | TMPRSS6 | GWAS association (p=1.0e-22) | Meta-analysis |
| rs6980507 | — | GWAS association (p=8.0e-20) | Meta-analysis |
| rs11154792 | — | GWAS association (p=7.0e-18) | Meta-analysis |
| rs9914988 | ERAL1 | GWAS association (p=5.0e-17) | Meta-analysis |
| rs35203608 | — | GWAS association (p=6.0e-17) | Meta-analysis |
| rs6474359 | ANK1 | GWAS association (p=2.0e-16) | Meta-analysis |
| rs17509001 | — | GWAS association (p=2.0e-15) | Meta-analysis |
| rs11248914 | — | GWAS association (p=1.0e-14) | Meta-analysis |
| rs7040409 | LOC124902205 | GWAS association (p=3.0e-14) | Meta-analysis |
| rs9818758 | — | GWAS association (p=1.0e-13) | Meta-analysis |
| rs282587 | — | GWAS association (p=2.0e-12) | Meta-analysis |
| rs7756992 | CDKAL1 | GWAS association (p=3.0e-12) | Meta-analysis |
| rs17533903 | — | GWAS association (p=5.0e-12) | Meta-analysis |
| rs2383208 | — | GWAS association (p=7.0e-12) | Meta-analysis |
| rs8192675 | SLC2A2 | GWAS association (p=1.0e-11) | Meta-analysis |
| rs267738 | CERS2 | GWAS association (p=1.0e-11) | Meta-analysis |
| rs12132919 | — | GWAS association (p=3.0e-11) | Meta-analysis |
| rs17747324 | TCF7L2 | GWAS association (p=6.0e-11) | Meta-analysis |
| rs3782123 | — | GWAS association (p=2.0e-10) | Meta-analysis |
| rs7616006 | — | GWAS association (p=5.0e-10) | Meta-analysis |
| rs11964178 | — | GWAS association (p=6.0e-10) | Meta-analysis |
| rs11086054 | — | GWAS association (p=2.0e-09) | Meta-analysis |
| rs2110073 | — | GWAS association (p=6.0e-09) | Meta-analysis |
| rs10168523 | — | GWAS association (p=9.0e-09) | Meta-analysis |
| rs579459 | — | GWAS association (p=9.0e-09) | Meta-analysis |
| rs9604573 | — | GWAS association (p=1.0e-08) | Meta-analysis |
| rs10774625 | ATXN2 | GWAS association (p=1.0e-08) | Meta-analysis |
| rs12621844 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs144991356 | — | GWAS association (p=3.0e-08) | Meta-analysis |
| rs1558902 | FTO | GWAS association (p=3.0e-08) | Meta-analysis |
| rs11954649 | SOX30 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs16926246 | HK1 | GWAS association (p=0.0e+00) | Major Consortium Study |
| rs34872471 | TCF7L2 | GWAS association (p=9.9e-324) | Major Consortium Study |
| rs17476364 | — | GWAS association (p=1.0e-314) | Major Consortium Study |
| rs569805 | ABCB11 | GWAS association (p=2.0e-277) | Major Consortium Study |
| rs730497 | GCK | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs113373052 | — | GWAS association (p=6.0e-246) | Major Consortium Study |
| rs7903146 | TCF7L2 | GWAS association (p=8.0e-234) | Major Consortium Study |
| rs4737010 | — | GWAS association (p=1.0e-227) | Major Consortium Study |
| rs855791 | TMPRSS6 | GWAS association (p=1.0e-212) | Major Consortium Study |
| rs857721 | SPTA1 | GWAS association (p=3.0e-194) | Major Consortium Study |
| rs906220 | HK1 | GWAS association (p=8.0e-166) | Major Consortium Study |
| rs41273491 | — | GWAS association (p=4.0e-152) | Major Consortium Study |
| rs7766070 | CDKAL1 | GWAS association (p=9.0e-152) | Major Consortium Study |
| rs454139 | — | GWAS association (p=4.0e-146) | Major Consortium Study |
| rs9859406 | — | GWAS association (p=6.0e-139) | Major Consortium Study |
| rs2852635 | SPTA1 | GWAS association (p=2.0e-136) | Major Consortium Study |
| rs76895963 | — | GWAS association (p=3.0e-130) | Major Consortium Study |
| rs35859536 | — | GWAS association (p=1.0e-113) | Major Consortium Study |
| rs34664882 | ANK1 | GWAS association (p=3.0e-113) | Major Consortium Study |
| rs10128330 | — | GWAS association (p=2.0e-109) | Major Consortium Study |
| rs10811660 | — | GWAS association (p=1.0e-94) | Major Consortium Study |
| rs73108053 | LOC102725258 | GWAS association (p=8.0e-92) | Major Consortium Study |
| rs144120533 | TMC8 | GWAS association (p=5.0e-88) | Major Consortium Study |
| rs1387153 | — | GWAS association (p=6.0e-86) | Major Consortium Study |
| rs334 | HBB | GWAS association (p=9.0e-85) | Major Consortium Study |
| rs376993806 | GPSM1 | GWAS association (p=1.0e-80) | Major Consortium Study |
| rs6844670 | — | GWAS association (p=3.0e-77) | Major Consortium Study |
| rs11552063 | — | GWAS association (p=1.0e-70) | Major Consortium Study |
| rs35365035 | — | GWAS association (p=2.0e-69) | Major Consortium Study |
| rs1175550 | SMIM1 | GWAS association (p=8.0e-69) | Major Consortium Study |
| rs201226914 | PIEZO1 | GWAS association (p=1.0e-68) | Major Consortium Study |
| rs507666 | ABO | GWAS association (p=5.0e-68) | Major Consortium Study |
| rs2235321 | TMPRSS6 | GWAS association (p=1.0e-66) | Major Consortium Study |
| rs36211745 | GYPA | GWAS association (p=2.0e-65) | Major Consortium Study |
| rs1635852 | JAZF1 | GWAS association (p=3.0e-60) | Major Consortium Study |
| rs1799945 | HFE | GWAS association (p=7.0e-60) | Major Consortium Study |
| rs9410411 | — | GWAS association (p=2.0e-59) | Major Consortium Study |
| rs2968478 | — | GWAS association (p=3.0e-59) | Major Consortium Study |
| rs11759026 | — | GWAS association (p=5.0e-58) | Major Consortium Study |
| rs76160968 | — | GWAS association (p=7.0e-57) | Major Consortium Study |
| rs4148646 | ABCC8 | GWAS association (p=4.0e-56) | Major Consortium Study |
| rs415895 | — | GWAS association (p=1.0e-55) | Major Consortium Study |
| rs34177044 | — | GWAS association (p=3.0e-55) | Major Consortium Study |
| rs2748424 | TMC6 | GWAS association (p=4.0e-55) | Major Consortium Study |
| rs2191349 | — | GWAS association (p=2.0e-54) | Major Consortium Study |
| rs80215559 | — | GWAS association (p=3.0e-53) | Major Consortium Study |
| rs5219 | KCNJ11 | GWAS association (p=8.0e-53) | Major Consortium Study |
| rs1579274 | — | GWAS association (p=2.0e-52) | Major Consortium Study |
| rs145091408 | FKBP1B | GWAS association (p=2.0e-52) | Major Consortium Study |
Showing the top 100 of 1,362 variants by evidence strength.
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.