FN3KRP
fructosamine 3 kinase related protein
Summary
A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Known Variants37 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs12937346 | 17:80,672,822 | T/A | — | — |
| rs758945172 | 17:80,674,648 | G/A | — | likely benign |
| rs748958920 | 17:80,674,654 | A/G | — | uncertain significance |
| rs754797996 | 17:80,674,659 | G/C | — | uncertain significance |
| rs773096689 | 17:80,674,680 | A/T | — | uncertain significance |
| rs765305815 | 17:80,674,692 | G/C | — | uncertain significance |
| rs550636711 | 17:80,674,708 | G/A | — | uncertain significance |
| rs200062745 | 17:80,674,710 | C/G | — | uncertain significance |
| rs376480630 | 17:80,674,725 | G/C | — | uncertain significance |
| rs1197597266 | 17:80,674,732 | A/G | — | uncertain significance |
| rs772306011 | 17:80,676,819 | C/T | — | uncertain significance |
| rs1568059603 | 17:80,678,158 | A/C | — | uncertain significance |
| rs750718633 | 17:80,678,215 | C/T | — | uncertain significance |
| rs372059941 | 17:80,680,703 | C/T | — | uncertain significance |
| rs201092965 | 17:80,680,704 | G/A | — | uncertain significance |
| rs375407644 | 17:80,680,723 | T/G | — | uncertain significance |
| rs893353540 | 17:80,680,752 | A/G | — | uncertain significance |
| rs967016381 | 17:80,680,761 | A/G | — | uncertain significance |
| rs149116457 | 17:80,684,396 | G/A | — | likely benign |
| rs142036101 | 17:80,684,446 | A/G | — | uncertain significance |
| rs757154257 | 17:80,684,467 | T/C | — | uncertain significance |
| rs556222572 | 17:80,684,806 | C/T | — | uncertain significance |
| rs374284375 | 17:80,684,813 | T/G | — | uncertain significance |
| rs1321239467 | 17:80,684,827 | C/A | — | uncertain significance |
| rs773166303 | 17:80,684,835 | G/A | — | uncertain significance |
| rs771035632 | 17:80,684,842 | C/T | — | uncertain significance |
| rs2510311978 | 17:80,684,868 | A/G | — | uncertain significance |
| rs2510311994 | 17:80,684,881 | T/C | — | uncertain significance |
| rs750927949 | 17:80,684,901 | G/A | — | uncertain significance |
| rs376337783 | 17:80,684,928 | C/A | — | uncertain significance |
| rs762977804 | 17:80,684,943 | C/T | — | uncertain significance |
| rs764337681 | 17:80,684,944 | G/A | — | uncertain significance |
| rs372015126 | 17:80,684,971 | A/G | — | uncertain significance |
| rs577164776 | 17:80,684,986 | A/C | — | uncertain significance |
| rs2510312137 | 17:80,685,012 | T/A | — | uncertain significance |
| rs1046875 | 17:80,685,426 | A/G | downstream gene variant | — |
| rs1046896 | 17:80,685,533 | C/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.