H1-6
H1.6 linker histone, cluster member
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
Known Variants39 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs198846 | 6:26,107,463 | A/C | — | — |
| rs1427596177 | 6:26,107,714 | G/C | — | uncertain significance |
| rs1278816856 | 6:26,107,754 | A/G | — | likely benign |
| rs1199969316 | 6:26,107,756 | T/C | — | uncertain significance |
| rs183955673 | 6:26,107,759 | G/A | — | uncertain significance |
| rs200394941 | 6:26,107,778 | G/A | — | uncertain significance |
| rs76722423 | 6:26,107,793 | G/T | — | uncertain significance |
| rs778073710 | 6:26,107,846 | G/C | — | uncertain significance |
| rs201974399 | 6:26,107,896 | C/G | — | uncertain significance |
| rs775518111 | 6:26,107,904 | C/A | — | uncertain significance |
| rs376395612 | 6:26,107,973 | G/A | — | uncertain significance |
| rs750017034 | 6:26,107,985 | T/C | — | uncertain significance |
| rs771871326 | 6:26,107,988 | T/C | — | uncertain significance |
| rs776843258 | 6:26,107,993 | T/C | — | uncertain significance |
| rs149988775 | 6:26,108,048 | C/T | — | uncertain significance |
| rs746084928 | 6:26,108,074 | C/T | — | uncertain significance |
| rs556299504 | 6:26,108,083 | T/C | — | uncertain significance |
| rs180928364 | 6:26,108,096 | C/G | — | uncertain significance |
| rs768139804 | 6:26,108,107 | G/A | — | uncertain significance |
| rs201389967 | 6:26,108,116 | G/A | — | uncertain significance |
| rs146860658 | 6:26,108,117 | C/T | missense variant | — |
| rs368165155 | 6:26,108,140 | A/G | — | uncertain significance |
| rs1235384395 | 6:26,108,141 | T/C | — | uncertain significance |
| rs763588642 | 6:26,108,149 | C/T | — | uncertain significance |
| rs61729268 | 6:26,108,173 | T/C | — | uncertain significance |
| rs141133387 | 6:26,108,180 | T/C | — | uncertain significance |
| rs376970828 | 6:26,108,185 | T/C | — | uncertain significance |
| rs766076084 | 6:26,108,186 | T/C | — | uncertain significance |
| rs199870319 | 6:26,108,198 | G/A | — | uncertain significance |
| rs781562286 | 6:26,108,200 | T/G | — | uncertain significance |
| rs201315830 | 6:26,108,210 | T/G | — | uncertain significance |
| rs746384390 | 6:26,108,226 | C/G | — | uncertain significance |
| rs753613931 | 6:26,108,233 | G/C | — | uncertain significance |
| rs564438649 | 6:26,108,236 | G/A | — | uncertain significance |
| rs745789402 | 6:26,108,275 | G/A | — | likely benign |
| rs769794056 | 6:26,108,276 | C/A | — | likely benign |
| rs198844 | 6:26,108,282 | C/T | missense variant | — |
| rs375287545 | 6:26,108,299 | G/A | — | uncertain significance |
| rs768829339 | 6:26,108,306 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.