GPSM1
G protein signaling modulator 1
Summary
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Known Variants78 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1300949168 | 9:139,222,168 | C/T | — | uncertain significance |
| rs1484507980 | 9:139,222,192 | G/A | — | uncertain significance |
| rs552621174 | 9:139,228,998 | G/A | — | uncertain significance |
| rs369488840 | 9:139,229,058 | G/A | — | uncertain significance |
| rs782695513 | 9:139,229,086 | G/A | — | uncertain significance |
| rs782582578 | 9:139,229,107 | A/T | — | uncertain significance |
| rs782476387 | 9:139,230,524 | G/A | — | uncertain significance |
| rs1554769327 | 9:139,231,381 | G/A | — | uncertain significance |
| rs782204726 | 9:139,231,396 | C/T | — | uncertain significance |
| rs188531960 | 9:139,231,407 | C/G | — | uncertain significance |
| rs782104546 | 9:139,231,414 | G/A | — | uncertain significance |
| rs2538597523 | 9:139,231,437 | A/C | — | uncertain significance |
| rs528339901 | 9:139,231,453 | G/A | — | uncertain significance |
| rs782583822 | 9:139,231,474 | G/A | — | uncertain significance |
| rs1326988572 | 9:139,231,496 | G/A | — | uncertain significance |
| rs370048416 | 9:139,231,932 | C/T | — | uncertain significance |
| rs782134064 | 9:139,231,939 | C/T | — | uncertain significance |
| rs200055599 | 9:139,232,005 | C/T | — | uncertain significance |
| rs782714950 | 9:139,232,304 | G/A | — | uncertain significance |
| rs782041406 | 9:139,232,312 | A/G | — | uncertain significance |
| rs1278475751 | 9:139,232,342 | G/A | — | uncertain significance |
| rs782301159 | 9:139,232,390 | C/T | — | uncertain significance |
| rs371874960 | 9:139,232,391 | G/A | — | uncertain significance |
| rs368166239 | 9:139,233,031 | C/T | — | uncertain significance |
| rs782499031 | 9:139,233,032 | G/A | — | uncertain significance |
| rs1554769691 | 9:139,233,052 | G/A | — | uncertain significance |
| rs146149038 | 9:139,233,116 | C/T | — | uncertain significance |
| rs782244000 | 9:139,233,134 | G/A | — | uncertain significance |
| rs368194568 | 9:139,233,145 | A/G | — | uncertain significance |
| rs1588695738 | 9:139,234,220 | G/A | — | uncertain significance |
| rs551509416 | 9:139,234,267 | C/G | — | uncertain significance |
| rs1554770094 | 9:139,235,328 | T/C | — | uncertain significance |
| rs917217200 | 9:139,235,337 | G/T | — | uncertain significance |
| rs1326908158 | 9:139,235,403 | G/T | — | uncertain significance |
| rs1163836463 | 9:139,235,422 | G/T | — | uncertain significance |
| rs3935875 | 9:139,238,824 | A/T | — | — |
| rs28641468 | 9:139,239,585 | T/C | intron variant | — |
| rs28505901 | 9:139,241,030 | A/G | intron variant | — |
| rs28562046 | 9:139,241,595 | C/G | intron variant | — |
| rs28533815 | 9:139,241,828 | T/C | intron variant | — |
| rs28463558 | 9:139,242,656 | C/T | intron variant | — |
| rs76185667 | 9:139,243,143 | C/T | — | likely benign |
| rs375017996 | 9:139,243,217 | C/T | — | uncertain significance |
| rs1482162323 | 9:139,244,069 | G/A | — | uncertain significance |
| rs1554771746 | 9:139,244,081 | C/T | — | uncertain significance |
| rs782378879 | 9:139,244,119 | G/T | — | uncertain significance |
| rs782090448 | 9:139,244,135 | C/T | — | uncertain significance |
| rs374353058 | 9:139,244,141 | G/A | — | uncertain significance |
| rs782422888 | 9:139,244,189 | G/A | — | uncertain significance |
| rs782139573 | 9:139,244,196 | G/A | — | uncertain significance |
| rs2538620087 | 9:139,244,201 | C/T | — | uncertain significance |
| rs782772079 | 9:139,244,214 | C/G | — | uncertain significance |
| rs376993806 | 9:139,246,588 | A/C | — | — |
| rs77684335 | 9:139,246,733 | A/C | — | — |
| rs138406802 | 9:139,246,766 | A/C | — | — |
| rs61386106 | 9:139,246,768 | G/A | intron variant | — |
| rs74604683 | 9:139,247,229 | C/T | regulatory region variant | — |
| rs782180704 | 9:139,250,220 | G/A | — | uncertain significance |
| rs199566409 | 9:139,250,241 | G/A | — | uncertain significance |
| rs782806943 | 9:139,250,253 | G/A | — | uncertain significance |
| rs559892379 | 9:139,250,803 | C/T | — | uncertain significance |
| rs2538632653 | 9:139,250,824 | C/T | — | uncertain significance |
| rs149029956 | 9:139,250,862 | C/T | — | uncertain significance |
| rs377665126 | 9:139,250,873 | C/A | — | uncertain significance |
| rs374358876 | 9:139,250,934 | C/A | — | uncertain significance |
| rs3923827 | 9:139,251,480 | C/G | — | — |
| rs11787792 | 9:139,252,148 | G/T | — | — |
| rs782062269 | 9:139,252,478 | G/A | — | uncertain significance |
| rs934050844 | 9:139,252,485 | A/G | — | uncertain significance |
| rs782414185 | 9:139,252,540 | C/G | — | uncertain significance |
| rs1554773545 | 9:139,252,550 | C/G | — | uncertain significance |
| rs371051646 | 9:139,252,568 | G/A | — | uncertain significance |
| rs375107438 | 9:139,252,574 | C/T | — | uncertain significance |
| rs782100419 | 9:139,252,604 | G/A | — | uncertain significance |
| rs782768965 | 9:139,252,628 | G/A | — | uncertain significance |
| rs373339173 | 9:139,252,632 | C/T | — | uncertain significance |
| rs957457301 | 9:139,252,665 | C/T | — | uncertain significance |
| rs782245108 | 9:139,252,668 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.