Trait
SNPs associated with Diabetic retinopathy
73 genetic variants across 32 genes have been associated with Diabetic retinopathy in published research. Key genes include ANK1, AP3S2, APOE.
Associated variants73 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs34872471 | TCF7L2 | GWAS association (p=3.0e-261) | Meta-analysis |
| rs9274619 | HLA-DQB1 | GWAS association (p=4.0e-39) | Meta-analysis |
| rs139220415 | — | GWAS association (p=2.0e-08) | Meta-analysis |
| rs7903146 | TCF7L2 | GWAS association (p=3.0e-271) | Major Consortium Study |
| rs7630554 | IGF2BP2 | GWAS association (p=2.0e-45) | Major Consortium Study |
| rs1801214 | WFS1 | GWAS association (p=7.0e-35) | Major Consortium Study |
| rs2237897 | KCNQ1 | GWAS association (p=1.0e-32) | Major Consortium Study |
| rs4933736 | — | GWAS association (p=2.0e-32) | Major Consortium Study |
| rs9274830 | — | GWAS association (p=2.0e-29) | Major Consortium Study |
| rs234864 | — | GWAS association (p=3.0e-27) | Major Consortium Study |
| rs9348441 | CDKAL1 | GWAS association (p=3.0e-26) | Major Consortium Study |
| rs13266634 | SLC30A8 | GWAS association (p=7.0e-26) | Major Consortium Study |
| rs459193 | C5orf67 | GWAS association (p=7.0e-25) | Major Consortium Study |
| rs9457 | WFS1 | GWAS association (p=2.0e-24) | Major Consortium Study |
| rs738408 | PNPLA3 | GWAS association (p=3.0e-22) | Major Consortium Study |
| rs2972156 | — | GWAS association (p=5.0e-22) | Major Consortium Study |
| rs3747207 | PNPLA3 | GWAS association (p=7.0e-22) | Major Consortium Study |
| rs111812200 | THADA | GWAS association (p=2.0e-21) | Major Consortium Study |
| rs10195252 | — | GWAS association (p=2.0e-21) | Major Consortium Study |
| rs11466334 | TGFB1 | GWAS association (p=6.0e-21) | Major Consortium Study |
| rs10184004 | — | GWAS association (p=9.0e-21) | Major Consortium Study |
| rs76160968 | — | GWAS association (p=3.0e-20) | Major Consortium Study |
| rs3759831 | AP3S2 | GWAS association (p=4.0e-18) | Major Consortium Study |
| rs4929965 | — | GWAS association (p=9.0e-18) | Major Consortium Study |
| rs1905376 | TRPS1 | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs11759026 | — | GWAS association (p=3.0e-17) | Major Consortium Study |
| rs3918298 | — | GWAS association (p=2.0e-16) | Major Consortium Study |
| rs11720108 | — | GWAS association (p=4.0e-16) | Major Consortium Study |
| rs10852123 | — | GWAS association (p=7.0e-16) | Major Consortium Study |
| rs35658696 | PAM | GWAS association (p=1.0e-15) | Major Consortium Study |
| rs12544241 | ANK1 | GWAS association (p=2.0e-15) | Major Consortium Study |
| rs1565756 | HMG20A | GWAS association (p=6.0e-15) | Major Consortium Study |
| rs11257655 | — | GWAS association (p=7.0e-15) | Major Consortium Study |
| rs1215468 | — | GWAS association (p=7.0e-15) | Major Consortium Study |
| rs11688682 | — | GWAS association (p=3.0e-14) | Major Consortium Study |
| rs1260326 | GCKR | GWAS association (p=4.0e-14) | Major Consortium Study |
| rs10842987 | — | GWAS association (p=6.0e-14) | Major Consortium Study |
| rs748179 | — | GWAS association (p=7.0e-14) | Major Consortium Study |
| rs376993806 | GPSM1 | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs10244051 | — | GWAS association (p=9.0e-14) | Major Consortium Study |
| rs71304101 | — | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs429358 | APOE | GWAS association (p=3.0e-13) | Major Consortium Study |
| rs12789028 | LTBP3 | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs9859406 | — | GWAS association (p=6.0e-13) | Major Consortium Study |
| rs60069508 | BMP8A | GWAS association (p=7.0e-13) | Major Consortium Study |
| rs61779313 | — | GWAS association (p=9.0e-13) | Major Consortium Study |
| rs35352848 | UBE2E2 | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs2540949 | — | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs12641981 | — | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs73001065 | — | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs1182443 | UBE3C | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs340874 | PROX1 | GWAS association (p=5.0e-12) | Major Consortium Study |
| rs4696136 | — | GWAS association (p=6.0e-12) | Major Consortium Study |
| rs348330 | — | GWAS association (p=1.0e-11) | Major Consortium Study |
| rs7156625 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs10407429 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs2796441 | TLE1-DT | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs59360790 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs11711477 | IGF2BP2 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs6777684 | LOC107986166 | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs76895963 | — | GWAS association (p=4.0e-19) | Major Consortium Study |
| rs1421085 | FTO | GWAS association (p=8.0e-74) | Major Consortium Study |
| rs243083 | — | GWAS association (p=1.0e-14) | Major Consortium Study |
| rs1635852 | JAZF1 | GWAS association (p=7.0e-24) | Major Consortium Study |
| rs10811661 | — | GWAS association (p=4.0e-44) | Major Consortium Study |
| rs12630354 | — | GWAS association (p=7.0e-10) | Large GWAS |
| rs3913535 | — | GWAS association (p=4.0e-09) | Large GWAS |
| rs11018670 | — | GWAS association (p=1.0e-08) | Large GWAS |
| rs17376456 | KIAA0825 | GWAS association (p=3.0e-15) | Small GWAS |
| rs2038823 | HS6ST3 | GWAS association (p=5.0e-11) | Small GWAS |
| rs4838605 | ARHGAP22 | GWAS association (p=2.0e-09) | Small GWAS |
| rs12219125 | — | GWAS association (p=9.0e-09) | Small GWAS |
| rs1050828 | G6PD | Increased risk of diabetic retinopathy | Candidate gene study |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.