rs2796441

This variant is located in the TLE1-DT gene.

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele G

OR —

p 5.0e-80

N 2,535,601

Large GWAS

multi-ancestry

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)

Allele G

OR 0.06

p 3.0e-55

N 1,407,282

Meta-analysisLarge GWAS

multi-ancestry

Mahajan A et al. “Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.” Nature Genetics 50(11):1505-1513 (2018)

Allele G

OR 1.07

p 4.0e-24

N 898,130

Large GWAS

European

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele G

OR 0.07

p 1.0e-26

N 667,504

Large GWAS

multi-ancestry

Xue A et al. “Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.” Nature Communications 9(1):2941 (2018)

Allele G

OR 0.07

p 2.0e-22

N 659,316

Large GWAS

multi-ancestry

Spracklen CN et al. “Identification of type 2 diabetes loci in 433,540 East Asian individuals.” Nature 582(7811):240-245 (2020)

Allele G

OR 1.08

p 1.0e-28

N 433,540

Large GWAS

East Asian

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 2.0e-35

N 432,648

Major Consortium StudyLarge GWAS

European

Huerta-Chagoya A et al. “Rare variant analyses in 51,256 type 2 diabetes cases and 370,487 controls reveal the pathogenicity spectrum of monogenic diabetes genes.” Nature Genetics 56(11):2370-2379 (2024)

Allele G

OR 0.08

p 2.0e-24

N 421,743

Large GWAS

multi-ancestry

Mahajan A et al. “Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.” Nature Genetics 54(5):560-572 (2022)

Allele G

OR 0.07

p 8.0e-26

N 251,740

Large GWAS

European

Ishigaki K et al. “Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.” Nature Genetics 52(7):669-679 (2020)

Allele G

OR 0.93

p 3.0e-19

N 210,865

Large GWAS

East Asian

Suzuki K et al. “Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.” Nature Genetics 51(3):379-386 (2019)

Allele G

OR 1.08

p 3.0e-19

N 191,764

Large GWAS

East Asian

Zhao W et al. “Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.” Nature Genetics 49(10):1450-1457 (2017)

Allele G

OR 0.06

p 8.0e-10

N 183,651

Large GWAS

multi-ancestry

Morris AP et al. “Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes” Nature Genetics (2012)

Allele G

OR 1.09

p 5.0e-9

N 69,033

Large GWAS

multi-ancestry

diabetic eye disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.06

p 7.0e-14

N 431,357

Major Consortium StudyLarge GWAS

European

diabetes mellitus, Drugs used in diabetes use measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 6.0e-13

N 404,034

Major Consortium StudyLarge GWAS

multi-ancestry

body mass index

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 7.0e-13

N 424,217

Major Consortium StudyLarge GWAS

European

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)

Allele G

OR 0.01

p 9.0e-11

N 1,122,049

Large GWAS

European

body weight

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 9.0e-13

N 425,537

Major Consortium StudyLarge GWAS

European

diabetic neuropathy

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.04

p 1.0e-11

N 434,644

Major Consortium StudyLarge GWAS

European

diabetic retinopathy

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 2.0e-11

N 432,209

Major Consortium StudyLarge GWAS

European

hemoglobin A1 measurement

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)

Allele A

OR 0.01

p 5.0e-11

N 415,403

Large GWAS

multi-ancestry

diabetes mellitus

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.05

p 1.0e-14

N 404,034

Major Consortium StudyLarge GWAS

multi-ancestry

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele G

OR 0.08

p 1.0e-12

N 394,626

Large GWAS

European

glucose measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele G

OR 0.02

p 6.0e-12

N 601,111

Major Consortium StudyLarge GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs2796441

GWAS Catalog Trait Associations (11)

type 2 diabetes mellitus

diabetic eye disease

diabetes mellitus, Drugs used in diabetes use measurement

body mass index

body weight

diabetic neuropathy

diabetic retinopathy

hemoglobin A1 measurement

diabetes mellitus

glucose measurement

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