ARHGAP22
Rho GTPase activating protein 22
Summary
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Known Variants76 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1355602862 | 10:49,654,444 | G/A | — | uncertain significance |
| rs139222347 | 10:49,654,462 | C/T | — | uncertain significance |
| rs76208937 | 10:49,654,545 | C/T | — | benign |
| rs147996079 | 10:49,654,549 | C/T | — | uncertain significance |
| rs776189077 | 10:49,654,580 | T/C | — | uncertain significance |
| rs375336457 | 10:49,654,621 | C/T | — | likely benign |
| rs141682688 | 10:49,654,622 | G/A | — | uncertain significance |
| rs903681856 | 10:49,654,642 | T/C | — | uncertain significance |
| rs373675879 | 10:49,658,320 | C/T | — | uncertain significance |
| rs3747853 | 10:49,658,338 | G/A | — | benign |
| rs1216994723 | 10:49,658,423 | G/T | — | uncertain significance |
| rs1325018689 | 10:49,658,449 | C/T | — | likely benign |
| rs749348410 | 10:49,658,454 | G/T | — | uncertain significance |
| rs776292832 | 10:49,658,481 | A/G | — | likely benign |
| rs756521559 | 10:49,658,536 | C/G | — | uncertain significance |
| rs778871687 | 10:49,658,581 | C/A | — | uncertain significance |
| rs1022745646 | 10:49,658,592 | C/T | — | uncertain significance |
| rs1243750508 | 10:49,658,664 | C/A | — | uncertain significance |
| rs78948042 | 10:49,658,678 | C/T | — | likely benign |
| rs1004060477 | 10:49,658,737 | G/A | — | uncertain significance |
| rs769696772 | 10:49,658,755 | G/A | — | uncertain significance |
| rs777718892 | 10:49,658,758 | G/A | — | uncertain significance |
| rs751770148 | 10:49,658,838 | C/T | — | uncertain significance |
| rs1270250106 | 10:49,658,844 | T/A | — | uncertain significance |
| rs1402941824 | 10:49,658,883 | G/C | — | uncertain significance |
| rs77203089 | 10:49,658,904 | T/C | — | uncertain significance |
| rs776139187 | 10:49,658,922 | C/T | — | uncertain significance |
| rs1326939284 | 10:49,658,962 | G/C | — | uncertain significance |
| rs771493613 | 10:49,658,980 | C/A | — | uncertain significance |
| rs956332153 | 10:49,659,022 | C/G | — | uncertain significance |
| rs567487606 | 10:49,659,091 | G/A | — | uncertain significance |
| rs1288828418 | 10:49,659,096 | G/A | — | uncertain significance |
| rs200055621 | 10:49,659,121 | C/T | — | uncertain significance |
| rs998432497 | 10:49,659,293 | A/G | — | likely benign |
| rs750166303 | 10:49,659,372 | G/A | — | likely benign |
| rs764897851 | 10:49,659,568 | T/C | — | likely benign |
| rs753842762 | 10:49,661,383 | G/A | — | uncertain significance |
| rs144924707 | 10:49,661,404 | C/T | — | uncertain significance |
| rs773944645 | 10:49,662,138 | T/C | — | uncertain significance |
| rs775166551 | 10:49,662,153 | T/G | — | uncertain significance |
| rs764575493 | 10:49,662,182 | T/C | — | uncertain significance |
| rs1335983269 | 10:49,663,080 | T/C | — | uncertain significance |
| rs763119711 | 10:49,663,092 | C/T | — | uncertain significance |
| rs760644302 | 10:49,663,160 | G/A | — | uncertain significance |
| rs1589447725 | 10:49,663,173 | T/C | — | uncertain significance |
| rs1589447755 | 10:49,663,179 | T/C | — | uncertain significance |
| rs776874081 | 10:49,667,788 | C/A | — | uncertain significance |
| rs752127827 | 10:49,667,802 | C/T | — | uncertain significance |
| rs144706855 | 10:49,667,803 | G/A | — | uncertain significance |
| rs535624070 | 10:49,667,821 | T/C | — | uncertain significance |
| rs141575110 | 10:49,667,833 | C/G | — | likely benign |
| rs534103925 | 10:49,667,871 | G/A | — | uncertain significance |
| rs2539711044 | 10:49,667,928 | A/G | — | uncertain significance |
| rs72783094 | 10:49,686,734 | A/G | intron variant | — |
| rs369200749 | 10:49,687,682 | C/T | — | uncertain significance |
| rs201381170 | 10:49,687,690 | G/A | — | uncertain significance |
| rs1554865047 | 10:49,687,792 | C/T | — | uncertain significance |
| rs4838605 | 10:49,699,957 | C/T | intron variant | — |
| rs10776612 | 10:49,735,563 | C/T | intron variant | — |
| rs576989219 | 10:49,760,471 | C/T | — | — |
| rs10776614 | 10:49,763,166 | T/A | — | — |
| rs148577877 | 10:49,763,544 | C/T | — | uncertain significance |
| rs756188755 | 10:49,763,583 | G/T | — | uncertain significance |
| rs1391800276 | 10:49,790,999 | T/A | — | uncertain significance |
| rs771004436 | 10:49,791,024 | T/C | — | uncertain significance |
| rs370486035 | 10:49,791,048 | G/A | — | uncertain significance |
| rs551965474 | 10:49,791,120 | C/T | — | uncertain significance |
| rs146683289 | 10:49,791,143 | G/A | — | uncertain significance |
| rs140291555 | 10:49,791,149 | C/T | — | uncertain significance |
| rs79069617 | 10:49,791,150 | G/A | — | uncertain significance |
| rs137922552 | 10:49,791,161 | C/T | — | uncertain significance |
| rs781514470 | 10:49,791,169 | C/A | — | uncertain significance |
| rs10491034 | 10:49,810,367 | G/A | — | — |
| rs796052167 | 10:49,812,828 | T/G | — | likely benign |
| rs2377521 | 10:49,820,014 | C/G | — | — |
| rs190219020 | 10:49,860,232 | A/G | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.