UBE2E2

ubiquitin conjugating enzyme E2 E2

Summary

Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants33 total

rsidPosition (GRCh37)AllelesClassClinVar
rs16962249673:23,250,225C/Auncertain significance
rs14837298863:23,250,227A/Guncertain significance
rs2005988673:23,250,281C/Tuncertain significance
rs9295155073:23,250,294A/Cuncertain significance
rs12264233093:23,250,326T/Cuncertain significance
rs14951353:23,258,571A/Gintron variant
rs570554943:23,265,407T/A
rs5308316103:23,265,895A/G
rs74284843:23,330,101A/Gregulatory region variant
rs76124633:23,336,450C/G
rs48585053:23,377,366C/G
rs1401980673:23,388,882A/Tintron variant
rs126308833:23,390,488C/T
rs126336133:23,390,507T/G
rs124894083:23,392,666C/Gintron variant
rs76346993:23,394,439C/G
rs1484621653:23,396,320C/Tintron variant
rs67959683:23,417,027A/T
rs738234723:23,435,498G/A
rs576250693:23,438,574A/Cdownstream gene variant
rs18459003:23,454,565A/C
rs353528483:23,455,582T/Cintron variant
rs76283723:23,466,255A/Cintron variant
rs14298336333:23,541,175G/Cuncertain significance
rs98303883:23,559,547A/Gintron variant
rs583368073:23,559,865C/T
rs569647573:23,586,128A/C
rs67813883:23,596,170A/C
rs2011744613:23,602,703G/A
rs2016340573:23,602,704T/C
rs126377223:23,605,325G/Aintron variant
rs713222003:23,614,390C/Aintron variant
rs764356323:23,632,174C/A

Gene information from NCBI Gene. Variant classifications from ClinVar.