UBE2E2
ubiquitin conjugating enzyme E2 E2
Summary
Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants33 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1696224967 | 3:23,250,225 | C/A | — | uncertain significance |
| rs1483729886 | 3:23,250,227 | A/G | — | uncertain significance |
| rs200598867 | 3:23,250,281 | C/T | — | uncertain significance |
| rs929515507 | 3:23,250,294 | A/C | — | uncertain significance |
| rs1226423309 | 3:23,250,326 | T/C | — | uncertain significance |
| rs1495135 | 3:23,258,571 | A/G | intron variant | — |
| rs57055494 | 3:23,265,407 | T/A | — | — |
| rs530831610 | 3:23,265,895 | A/G | — | — |
| rs7428484 | 3:23,330,101 | A/G | regulatory region variant | — |
| rs7612463 | 3:23,336,450 | C/G | — | — |
| rs4858505 | 3:23,377,366 | C/G | — | — |
| rs140198067 | 3:23,388,882 | A/T | intron variant | — |
| rs12630883 | 3:23,390,488 | C/T | — | — |
| rs12633613 | 3:23,390,507 | T/G | — | — |
| rs12489408 | 3:23,392,666 | C/G | intron variant | — |
| rs7634699 | 3:23,394,439 | C/G | — | — |
| rs148462165 | 3:23,396,320 | C/T | intron variant | — |
| rs6795968 | 3:23,417,027 | A/T | — | — |
| rs73823472 | 3:23,435,498 | G/A | — | — |
| rs57625069 | 3:23,438,574 | A/C | downstream gene variant | — |
| rs1845900 | 3:23,454,565 | A/C | — | — |
| rs35352848 | 3:23,455,582 | T/C | intron variant | — |
| rs7628372 | 3:23,466,255 | A/C | intron variant | — |
| rs1429833633 | 3:23,541,175 | G/C | — | uncertain significance |
| rs9830388 | 3:23,559,547 | A/G | intron variant | — |
| rs58336807 | 3:23,559,865 | C/T | — | — |
| rs56964757 | 3:23,586,128 | A/C | — | — |
| rs6781388 | 3:23,596,170 | A/C | — | — |
| rs201174461 | 3:23,602,703 | G/A | — | — |
| rs201634057 | 3:23,602,704 | T/C | — | — |
| rs12637722 | 3:23,605,325 | G/A | intron variant | — |
| rs71322200 | 3:23,614,390 | C/A | intron variant | — |
| rs76435632 | 3:23,632,174 | C/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.