rs9830388

This is a intron variant variant in the UBE2E2 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

RR interval, trait in response to tetracyclic antidepressant, response to tricyclic antidepressant

Noordam R et al. “A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.” Journal of Medical Genetics 54(5):313-323 (2017)

Allele A

OR 25.20

p 2.0e-8

N 69,749

Major Consortium StudyLarge GWAS

multi-ancestry

About UBE2E2

Enables ISG15 transferase activity and ubiquitin conjugating enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within DNA damage response and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Implicated in type 2 diabetes mellitus. [provided by Alliance of Genome Resources, Jul 2025]

View all UBE2E2 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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