ARAP1

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Summary

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Known Variants124 total

rsidPosition (GRCh37)AllelesClassClinVar
rs185563852311:72,396,714C/T—uncertain significance
rs37180618511:72,397,100G/A—uncertain significance
rs77683161111:72,397,145C/T—uncertain significance
rs37720103411:72,397,152G/C—uncertain significance
rs76851041211:72,397,193C/A—uncertain significance
rs77881995711:72,397,194G/A—uncertain significance
rs229128811:72,397,200C/T—benign
rs57307869611:72,397,203G/A—uncertain significance
rs102918602111:72,398,496A/T—uncertain significance
rs76232406411:72,398,516G/A—uncertain significance
rs90061511:72,400,596A/Gintron variant—
rs19996147011:72,403,820G/A—uncertain significance
rs53133962011:72,404,371C/T—uncertain significance
rs213549655711:72,404,372G/A—uncertain significance
rs118635048811:72,404,440G/A—uncertain significance
rs141478217811:72,404,441G/C—uncertain significance
rs168704602411:72,404,491T/C—uncertain significance
rs76206245511:72,404,509C/T—likely benign
rs14701665611:72,404,847C/T—uncertain significance
rs7914584311:72,404,893C/A——
rs156521106311:72,406,091G/A—uncertain significance
rs14928342511:72,406,437T/A—uncertain significance
rs75522562211:72,406,440G/A—uncertain significance
rs93405235711:72,406,475A/G—uncertain significance
rs37523986811:72,406,494C/T—uncertain significance
rs37342112511:72,406,806C/T—uncertain significance
rs76881499211:72,406,807G/A—uncertain significance
rs126860734011:72,406,809C/A—uncertain significance
rs78002528911:72,407,640G/C—uncertain significance
rs117137366311:72,407,669C/G—uncertain significance
rs138248078011:72,407,696A/G—uncertain significance
rs5620088911:72,408,055G/C—benign
rs20036572611:72,408,063G/T—uncertain significance
rs7352966811:72,408,077A/C—benign
rs100361512111:72,408,078G/T—uncertain significance
rs135023724511:72,408,111G/A—uncertain significance
rs77594521111:72,408,130G/C—uncertain significance
rs142431120611:72,408,193T/C—uncertain significance
rs36764891011:72,408,229C/G—uncertain significance
rs249693094511:72,408,397T/C—uncertain significance
rs13820986511:72,408,401C/G—uncertain significance
rs133594059411:72,408,497A/T—uncertain significance
rs53243187811:72,408,649C/T—uncertain significance
rs249693376211:72,408,662C/T—uncertain significance
rs129594786511:72,408,970T/C—uncertain significance
rs75102674511:72,408,985G/A—uncertain significance
rs36851251111:72,409,018C/T—likely benign
rs75171403311:72,409,102C/T—uncertain significance
rs57737495211:72,409,103G/A—uncertain significance
rs18689032111:72,409,115G/A—uncertain significance
rs249694598011:72,410,069C/T—uncertain significance
rs15006675311:72,410,452G/T—likely benign
rs185637364711:72,410,484C/G—uncertain significance
rs77408403211:72,410,502C/T—uncertain significance
rs20150264411:72,410,522T/C—uncertain significance
rs37013995611:72,410,538G/A—uncertain significance
rs20168207811:72,412,708C/T—uncertain significance
rs185649313211:72,412,802G/T—uncertain significance
rs14447928511:72,412,838C/T—benign
rs77886550511:72,413,959G/A—uncertain significance
rs118133072711:72,414,013C/T—uncertain significance
rs75017687711:72,414,078G/A—uncertain significance
rs20106807811:72,415,237C/T—uncertain significance
rs36853326711:72,415,240C/T—uncertain significance
rs77168381511:72,415,285G/C—uncertain significance
rs14199094511:72,415,324G/A—uncertain significance
rs75096662311:72,415,334C/G—uncertain significance
rs75538240711:72,415,346G/A—uncertain significance
rs36781787211:72,415,355C/T—uncertain significance
rs90061611:72,416,325C/Gcoding sequence variant—
rs75475743511:72,418,229G/A—uncertain significance
rs249701389711:72,418,244C/A—uncertain significance
rs77769291911:72,420,924C/T—uncertain significance
rs14766327011:72,420,951C/T—uncertain significance
rs75913543511:72,420,954C/T—uncertain significance
rs76462117711:72,420,955G/A—uncertain significance
rs20163646311:72,420,979C/T—uncertain significance
rs14220122511:72,420,987T/C—uncertain significance
rs74885634711:72,421,459C/T—uncertain significance
rs14545121011:72,421,468C/T—uncertain significance
rs14089048411:72,421,492A/G—uncertain significance
rs13836463611:72,421,519G/A—uncertain significance
rs14337190411:72,421,575C/T—uncertain significance
rs14837732011:72,421,581C/T—likely benign
rs20077919711:72,422,171G/A—uncertain significance
rs249704556111:72,422,506G/T—uncertain significance
rs76702229311:72,422,535G/C—uncertain significance
rs14977295311:72,423,246C/T—benign
rs97839871011:72,423,268C/T—uncertain significance
rs75065726911:72,423,290C/T—likely benign
rs53612330311:72,423,502C/T—uncertain significance
rs249705381211:72,423,537C/T—uncertain significance
rs77177271911:72,423,577G/A—uncertain significance
rs11555600411:72,423,600G/A—benign
rs7450676511:72,424,012G/Cdownstream gene variant—
rs76134246011:72,425,205G/A—uncertain significance
rs77321241211:72,425,215G/A—uncertain significance
rs76663588311:72,425,220G/A—uncertain significance
rs117793721111:72,425,235T/G—uncertain significance
rs37722209211:72,425,238G/A—uncertain significance

Showing 100 of 124 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.