ADAMTS16
ADAM metallopeptidase with thrombospondin type 1 motif 16
Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
Known Variants87 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs752370037 | 5:5,140,594 | C/T | — | uncertain significance |
| rs758819088 | 5:5,140,785 | G/T | — | likely benign |
| rs769958940 | 5:5,140,805 | C/T | — | uncertain significance |
| rs770783756 | 5:5,140,810 | G/T | — | likely benign |
| rs1407733559 | 5:5,140,847 | C/T | — | uncertain significance |
| rs1018938800 | 5:5,140,859 | C/G | — | uncertain significance |
| rs270195 | 5:5,142,353 | A/T | coding sequence variant | — |
| rs2477504178 | 5:5,146,305 | A/G | — | uncertain significance |
| rs368411395 | 5:5,146,321 | G/A | — | uncertain significance |
| rs2086310 | 5:5,146,335 | C/G | missense variant | — |
| rs375824676 | 5:5,146,351 | A/G | — | uncertain significance |
| rs766063759 | 5:5,146,398 | G/T | — | uncertain significance |
| rs1289090502 | 5:5,146,527 | C/T | — | uncertain significance |
| rs376978039 | 5:5,182,175 | G/A | — | uncertain significance |
| rs2477222645 | 5:5,182,196 | A/G | — | uncertain significance |
| rs1441081029 | 5:5,182,198 | G/T | — | uncertain significance |
| rs369076448 | 5:5,182,205 | C/T | — | uncertain significance |
| rs72647742 | 5:5,182,242 | A/G | — | uncertain significance |
| rs768570224 | 5:5,182,262 | G/A | — | likely benign |
| rs200574267 | 5:5,182,295 | C/G | — | uncertain significance |
| rs115892769 | 5:5,182,364 | G/A | — | uncertain significance |
| rs202209661 | 5:5,182,370 | C/T | — | uncertain significance |
| rs370134938 | 5:5,186,213 | A/G | — | uncertain significance |
| rs373108200 | 5:5,186,236 | C/T | — | uncertain significance |
| rs1431159881 | 5:5,186,237 | G/T | — | uncertain significance |
| rs201747003 | 5:5,186,324 | A/G | — | uncertain significance |
| rs144922795 | 5:5,187,830 | T/A | — | likely benign |
| rs372920104 | 5:5,190,107 | C/T | — | likely benign |
| rs749506130 | 5:5,190,124 | G/A | — | uncertain significance |
| rs368918485 | 5:5,190,148 | G/A | — | uncertain significance |
| rs149781386 | 5:5,191,346 | G/A | intron variant | — |
| rs2477271643 | 5:5,200,305 | G/A | — | uncertain significance |
| rs1338856565 | 5:5,209,214 | A/C | — | uncertain significance |
| rs2477295040 | 5:5,209,276 | C/T | — | uncertain significance |
| rs150478708 | 5:5,209,295 | C/T | — | uncertain significance |
| rs377507889 | 5:5,235,165 | G/A | — | uncertain significance |
| rs201133379 | 5:5,235,171 | T/C | — | uncertain significance |
| rs202081208 | 5:5,235,201 | G/A | — | uncertain significance |
| rs1737060733 | 5:5,235,234 | C/T | — | uncertain significance |
| rs2477370938 | 5:5,237,102 | T/C | — | uncertain significance |
| rs2964433 | 5:5,237,597 | G/C | — | — |
| rs2477377411 | 5:5,239,266 | A/T | — | uncertain significance |
| rs68077031 | 5:5,239,309 | A/G | — | benign |
| rs74417218 | 5:5,239,855 | C/T | — | likely benign |
| rs753926712 | 5:5,239,931 | C/T | — | uncertain significance |
| rs750668749 | 5:5,239,938 | G/A | — | uncertain significance |
| rs1204784330 | 5:5,239,976 | T/G | — | uncertain significance |
| rs548389280 | 5:5,240,016 | C/A | — | uncertain significance |
| rs72647759 | 5:5,240,017 | A/C | — | likely benign |
| rs200262904 | 5:5,240,020 | C/A | — | uncertain significance |
| rs770133400 | 5:5,242,217 | C/T | — | uncertain significance |
| rs199708869 | 5:5,242,220 | T/G | — | uncertain significance |
| rs1405813845 | 5:5,242,284 | G/A | — | uncertain significance |
| rs777995259 | 5:5,242,289 | G/A | — | uncertain significance |
| rs765288305 | 5:5,242,296 | G/A | — | uncertain significance |
| rs2477444371 | 5:5,262,811 | T/C | — | uncertain significance |
| rs192673903 | 5:5,262,857 | C/T | — | uncertain significance |
| rs755948868 | 5:5,262,883 | G/T | — | uncertain significance |
| rs13172105 | 5:5,289,582 | A/C | intron variant | — |
| rs16875288 | 5:5,297,200 | A/T | intron variant | — |
| rs776323530 | 5:5,303,404 | C/T | — | uncertain significance |
| rs959697879 | 5:5,303,413 | G/A | — | uncertain significance |
| rs564663324 | 5:5,303,460 | C/T | — | uncertain significance |
| rs769507235 | 5:5,303,476 | C/G | — | uncertain significance |
| rs372400608 | 5:5,303,488 | C/T | — | uncertain significance |
| rs1036729111 | 5:5,303,554 | C/T | — | uncertain significance |
| rs201934118 | 5:5,303,749 | C/T | — | uncertain significance |
| rs369804339 | 5:5,303,772 | G/A | — | uncertain significance |
| rs200742357 | 5:5,303,811 | G/A | — | uncertain significance |
| rs1181037718 | 5:5,303,823 | C/G | — | uncertain significance |
| rs201662436 | 5:5,306,630 | G/A | — | uncertain significance |
| rs200073500 | 5:5,306,689 | T/C | — | uncertain significance |
| rs759136995 | 5:5,306,743 | C/A | — | uncertain significance |
| rs199905954 | 5:5,306,757 | C/T | — | likely benign |
| rs372733019 | 5:5,318,251 | C/T | — | uncertain significance |
| rs2477617159 | 5:5,318,254 | C/T | — | uncertain significance |
| rs1218334695 | 5:5,318,280 | A/T | — | uncertain significance |
| rs746561406 | 5:5,318,308 | G/A | — | uncertain significance |
| rs764403007 | 5:5,318,350 | C/T | — | uncertain significance |
| rs754582318 | 5:5,318,353 | T/G | — | uncertain significance |
| rs200916127 | 5:5,318,365 | C/T | — | uncertain significance |
| rs149219536 | 5:5,318,402 | C/T | — | likely benign |
| rs1561010314 | 5:5,319,154 | A/G | — | uncertain significance |
| rs145851675 | 5:5,319,185 | C/T | — | likely benign |
| rs931637654 | 5:5,319,198 | C/T | — | uncertain significance |
| rs756225310 | 5:5,319,210 | G/A | — | uncertain significance |
| rs370378266 | 5:5,319,225 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.