rs16875288
This is a intron variant variant in the ADAMTS16 gene.
▶Research that mentions this SNP (1)
▶Genetic predictors of risk and resilience in psychiatric disorders: A cross‐disorder genome‐wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophreniaAssociationN=2,246Lauren M. McGrath et al.(2013)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A genome-wide association study of 2,246 psychiatric patients across three disorders (MDD, bipolar disorder, schizophrenia) identified variants in ADAMTS16 showing the strongest association with physical health-related quality of life (rs16875288, p = 5.87 × 10⁻⁸, approaching but not exceeding genome-wide significance). The findings demonstrate that genetic variation in functional impairment operates as a distinct axis independent from symptom severity, with psychiatric symptoms accounting for less than one-third of the variance in functional outcomes.
About ADAMTS16
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may inhibit chondrosarcoma cell proliferation and migration. This gene may regulate blood pressure. [provided by RefSeq, May 2016]
View all ADAMTS16 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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