ADRA2B
adrenoceptor alpha 2B
Summary
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs186085130 | 2:96,780,543 | G/T | — | likely benign |
| rs775606736 | 2:96,780,605 | C/T | — | likely benign |
| rs201182537 | 2:96,780,632 | G/A | — | likely benign |
| rs541934198 | 2:96,780,656 | G/A | — | likely benign |
| rs746796877 | 2:96,780,665 | G/A | — | likely benign |
| rs1004815866 | 2:96,780,712 | T/C | — | uncertain significance |
| rs2229169 | 2:96,780,716 | T/G | synonymous variant | — |
| rs29000569 | 2:96,780,763 | C/T | — | likely benign |
| rs774541477 | 2:96,780,771 | A/C | — | uncertain significance |
| rs1431850417 | 2:96,780,772 | C/T | — | likely benign |
| rs766867633 | 2:96,780,796 | G/A | — | uncertain significance |
| rs571112964 | 2:96,780,805 | G/A | — | uncertain significance |
| rs757853154 | 2:96,780,819 | C/T | — | uncertain significance |
| rs2467052384 | 2:96,780,828 | C/T | — | not provided |
| rs2467052404 | 2:96,780,840 | C/T | — | uncertain significance |
| rs200278633 | 2:96,780,955 | C/G | — | uncertain significance |
| rs750340969 | 2:96,781,015 | A/G | — | uncertain significance |
| rs553348015 | 2:96,781,053 | T/C | — | uncertain significance |
| rs1681842123 | 2:96,781,106 | G/A | — | likely benign |
| rs1049900125 | 2:96,781,194 | G/C | — | uncertain significance |
| rs786205528 | 2:96,781,225 | G/A | stop gained | pathogenic |
| rs371934652 | 2:96,781,240 | C/T | — | uncertain significance |
| rs773036430 | 2:96,781,261 | T/C | — | uncertain significance |
| rs372356977 | 2:96,781,321 | G/A | — | uncertain significance |
| rs375131185 | 2:96,781,322 | G/A | — | benign |
| rs780898618 | 2:96,781,376 | C/G | — | uncertain significance |
| rs775577204 | 2:96,781,399 | A/G | — | uncertain significance |
| rs749124572 | 2:96,781,406 | G/A | — | likely benign |
| rs771208116 | 2:96,781,507 | G/T | — | uncertain significance |
| rs2467054959 | 2:96,781,510 | G/T | — | uncertain significance |
| rs368204339 | 2:96,781,596 | G/T | — | uncertain significance |
| rs1681862655 | 2:96,781,609 | G/C | — | uncertain significance |
| rs1057520077 | 2:96,781,613 | G/C | — | uncertain significance |
| rs1397681630 | 2:96,781,615 | C/T | — | uncertain significance |
| rs746794661 | 2:96,781,647 | C/T | — | uncertain significance |
| rs191996571 | 2:96,781,687 | A/T | — | uncertain significance |
| rs868823059 | 2:96,781,744 | G/A | — | likely benign |
| rs35812638 | 2:96,781,769 | G/A | — | benign |
| rs1307026683 | 2:96,781,773 | G/A | — | likely pathogenic |
| rs2467055762 | 2:96,781,810 | T/C | — | uncertain significance |
| rs9333567 | 2:96,781,853 | C/T | — | benign |
| rs750207825 | 2:96,781,868 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.