ADRB3
adrenoceptor beta 3
Summary
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Known Variants29 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4998 | 8:37,821,486 | C/G | — | benign |
| rs2071493 | 8:37,821,853 | T/C | — | benign |
| rs4997 | 8:37,822,769 | C/A | — | benign |
| rs533964715 | 8:37,822,868 | C/A | — | uncertain significance |
| rs36031925 | 8:37,822,931 | G/A | — | benign |
| rs1456854445 | 8:37,822,961 | G/C | — | uncertain significance |
| rs200277866 | 8:37,822,975 | T/C | — | uncertain significance |
| rs781345130 | 8:37,823,003 | G/A | — | uncertain significance |
| rs780502227 | 8:37,823,010 | C/A | — | likely benign |
| rs771187056 | 8:37,823,203 | G/C | — | uncertain significance |
| rs1808290756 | 8:37,823,204 | G/A | — | uncertain significance |
| rs1196664028 | 8:37,823,221 | C/A | — | uncertain significance |
| rs72549191 | 8:37,823,246 | C/G | — | uncertain significance |
| rs1426434862 | 8:37,823,291 | G/T | — | uncertain significance |
| rs555759809 | 8:37,823,296 | G/A | — | uncertain significance |
| rs200163984 | 8:37,823,410 | G/C | — | uncertain significance |
| rs773838966 | 8:37,823,459 | A/G | — | uncertain significance |
| rs201338035 | 8:37,823,528 | C/A | — | uncertain significance |
| rs200133226 | 8:37,823,536 | T/C | — | uncertain significance |
| rs201123676 | 8:37,823,593 | G/T | — | uncertain significance |
| rs758511084 | 8:37,823,614 | A/G | — | uncertain significance |
| rs2486630651 | 8:37,823,686 | C/A | — | uncertain significance |
| rs1808314734 | 8:37,823,786 | G/A | — | uncertain significance |
| rs4994 | 8:37,823,798 | A/G | missense variant | risk factor |
| rs1808315675 | 8:37,823,819 | G/C | — | uncertain significance |
| rs2486631322 | 8:37,823,863 | G/T | — | uncertain significance |
| rs202143668 | 8:37,823,934 | G/C | — | benign |
| rs200142610 | 8:37,823,939 | G/A | — | uncertain significance |
| rs772084969 | 8:37,823,972 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.