AKT2

AKT serine/threonine kinase 2

Summary

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]

Known Variants162 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs33933140	19:40,739,513	A/G	—	benign
rs2304186	19:40,739,721	G/T	3 prime UTR variant	benign
rs79275829	19:40,739,770	G/A	—	likely benign
rs199536208	19:40,739,812	G/C	—	likely benign
rs142926499	19:40,739,826	G/A	—	conflicting classifications of pathogenicity
rs191069336	19:40,739,865	G/A	—	likely benign
rs746610906	19:40,739,867	G/A	—	likely benign
rs187555784	19:40,740,846	T/C	—	likely benign
rs375549081	19:40,740,932	C/T	—	likely benign
rs148795214	19:40,740,933	G/A	—	likely benign
rs757239082	19:40,740,955	G/A	—	uncertain significance
rs747244542	19:40,740,986	G/A	—	likely benign
rs1973933516	19:40,741,007	C/T	—	likely benign
rs56098986	19:40,741,022	G/A	—	benign
rs375739695	19:40,741,026	G/A	—	uncertain significance
rs1399189737	19:40,741,032	T/C	—	uncertain significance
rs760343615	19:40,741,037	T/C	—	likely benign
rs763704160	19:40,741,058	C/A	—	likely benign
rs771065673	19:40,741,187	C/T	—	conflicting classifications of pathogenicity
rs774681177	19:40,741,206	G/A	—	likely benign
rs765026585	19:40,741,247	C/G	—	uncertain significance
rs2145160063	19:40,741,267	G/C	—	likely benign
rs371347299	19:40,741,269	C/T	—	likely benign
rs3730264	19:40,741,274	G/A	—	benign
rs3730055	19:40,741,694	T/C	—	benign
rs145977456	19:40,741,847	G/A	—	likely benign
rs777146223	19:40,741,855	G/C	—	uncertain significance
rs139506765	19:40,741,857	G/A	—	uncertain significance
rs778561687	19:40,741,860	C/T	missense variant	uncertain significance
rs41309435	19:40,741,862	C/A	—	likely benign
rs1568518681	19:40,741,882	T/C	—	uncertain significance
rs1026908617	19:40,741,903	G/A	—	likely benign
rs755530378	19:40,741,904	C/T	—	likely benign
rs781682925	19:40,741,907	G/A	—	likely benign
rs1020231672	19:40,741,920	T/C	—	uncertain significance
rs1450407517	19:40,741,930	G/A	—	likely benign
rs202125073	19:40,741,932	C/T	—	uncertain significance
rs145305228	19:40,741,933	G/A	—	uncertain significance
rs1169786300	19:40,741,936	C/T	—	uncertain significance
rs372625056	19:40,741,940	C/T	—	likely benign
rs147634759	19:40,741,949	G/A	—	likely benign
rs188710541	19:40,741,982	G/A	—	likely benign
rs970521940	19:40,741,988	G/C	—	uncertain significance
rs367671463	19:40,742,024	G/A	—	likely benign
rs2304188	19:40,742,105	T/C	—	benign
rs749324936	19:40,742,144	C/A	—	likely benign
rs56165898	19:40,742,161	C/A	—	uncertain significance
rs587780278	19:40,742,164	C/T	—	uncertain significance
rs150000674	19:40,742,179	C/T	—	conflicting classifications of pathogenicity
rs1057519754	19:40,742,220	T/C	missense variant	—
rs587780277	19:40,742,263	G/T	—	uncertain significance
rs536687170	19:40,742,299	G/A	—	likely benign
rs2304189	19:40,742,320	T/C	—	benign
rs3730262	19:40,743,694	T/C	—	benign
rs200438281	19:40,743,858	G/A	—	benign
rs2145177700	19:40,743,866	T/C	—	likely benign
rs770347484	19:40,743,872	T/C	—	conflicting classifications of pathogenicity
rs758906645	19:40,743,885	G/A	—	likely benign
rs121434593	19:40,743,886	C/T	missense variant	pathogenic
rs182481170	19:40,743,915	C/T	—	likely benign
rs781527200	19:40,743,950	G/A	—	likely benign
rs749826058	19:40,743,963	T/C	—	uncertain significance
rs776435289	19:40,743,996	C/G	—	likely benign
rs370790932	19:40,744,001	G/C	—	uncertain significance
rs2145179062	19:40,744,007	G/A	—	likely benign
rs750276003	19:40,744,009	A/T	—	likely benign
rs17846833	19:40,744,012	G/A	—	benign
rs3730052	19:40,744,548	C/T	—	benign
rs3730051	19:40,744,697	T/C	—	benign
rs377332467	19:40,744,803	G/A	—	likely benign
rs185154487	19:40,744,804	C/T	—	likely benign
rs375480876	19:40,744,805	G/A	—	uncertain significance
rs2514270752	19:40,744,816	C/A	—	uncertain significance
rs765477884	19:40,744,821	G/A	—	likely benign
rs199761368	19:40,744,854	G/A	—	benign
rs371334732	19:40,744,863	G/A	—	likely benign
rs758767505	19:40,744,879	G/A	—	uncertain significance
rs2514271261	19:40,744,900	G/A	—	likely benign
rs367714258	19:40,745,941	G/C	—	likely benign
rs35817154	19:40,745,968	C/T	missense variant	uncertain significance
rs538944575	19:40,745,994	G/A	—	likely benign
rs771299029	19:40,746,009	G/A	—	likely benign
rs774646421	19:40,746,015	A/C	—	uncertain significance
rs2514277788	19:40,746,016	T/C	—	uncertain significance
rs553646470	19:40,746,032	C/T	—	likely benign
rs536203851	19:40,746,033	G/A	—	likely benign
rs75428690	19:40,747,533	G/A	—	benign
rs66468937	19:40,747,717	T/G	—	benign
rs3730259	19:40,747,820	C/G	—	benign
rs3730258	19:40,747,836	G/A	—	benign
rs200843500	19:40,747,837	G/A	—	likely benign
rs759277032	19:40,747,846	T/C	—	uncertain significance
rs752597471	19:40,747,868	G/A	—	uncertain significance
rs1974436210	19:40,747,887	G/A	—	uncertain significance
rs764058037	19:40,747,891	C/A	—	uncertain significance
rs757233968	19:40,747,892	G/A	—	uncertain significance
rs1209741122	19:40,747,893	G/A	—	likely benign
rs1599981221	19:40,747,902	C/T	—	likely benign
rs572670425	19:40,747,910	G/A	—	uncertain significance
rs1048317051	19:40,747,932	G/A	—	likely benign

Showing 100 of 162 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.