rs771065673
This variant is located in the AKT2 gene.
▶ClinVar annotation
Inborn genetic diseases; Type 2 diabetes mellitus;Hypoinsulinemic hypoglycemia and body hemihypertrophy
View on ClinVar →About AKT2
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. The gene serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins, and has also been implicated in insulin signaling. [provided by RefSeq, Nov 2019]
View all AKT2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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