ALOX15B

arachidonate 15-lipoxygenase type B

Summary

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Known Variants58 total

rsidPosition (GRCh37)AllelesClassClinVar
rs254543700517:7,942,570A/T—uncertain significance
rs57772959917:7,942,582C/T—uncertain significance
rs77129641217:7,942,592A/G—uncertain significance
rs77616198817:7,942,768A/T—uncertain significance
rs76592568417:7,942,794G/C—uncertain significance
rs20006529217:7,942,807C/G—uncertain significance
rs36831155617:7,942,824C/T—uncertain significance
rs77283160517:7,942,848C/T—uncertain significance
rs76735685117:7,942,868C/A—uncertain significance
rs91762770817:7,942,869C/A—uncertain significance
rs57752724017:7,943,249G/A—uncertain significance
rs76379037317:7,943,275G/C—uncertain significance
rs13980028717:7,945,725A/G—likely benign
rs132311294817:7,945,739G/A—likely benign
rs127714599117:7,945,743A/G—uncertain significance
rs90554872617:7,946,148A/G—uncertain significance
rs75071382117:7,946,179A/C—uncertain significance
rs14388323017:7,948,152G/A—likely benign
rs14153408617:7,948,239C/T—likely benign
rs56729162117:7,948,253C/A—uncertain significance
rs20148069617:7,948,257G/T—uncertain significance
rs36786726417:7,948,269A/G—uncertain significance
rs14618426217:7,948,293G/A—uncertain significance
rs133474233017:7,948,317G/C—uncertain significance
rs75737749117:7,948,559G/A—uncertain significance
rs13888322217:7,948,560G/A—uncertain significance
rs124611943617:7,948,602A/G—likely benign
rs36775840117:7,948,680C/T—uncertain significance
rs14949068517:7,948,693C/T—likely benign
rs11177715917:7,948,795C/T—benign
rs14596845417:7,948,829C/T—uncertain significance
rs254544453817:7,948,835T/G—uncertain significance
rs37043443617:7,948,885C/T—uncertain significance
rs125007683517:7,948,897T/A—uncertain significance
rs254544476817:7,948,997T/C—uncertain significance
rs119633216017:7,950,071G/T—uncertain significance
rs134033400817:7,950,234A/G—uncertain significance
rs14857824717:7,950,237G/A—uncertain significance
rs254544628917:7,950,289A/G—uncertain significance
rs156797291317:7,950,292C/G—uncertain significance
rs14062347817:7,950,319G/A—uncertain significance
rs77699152517:7,950,647C/A—uncertain significance
rs14154987017:7,950,692G/A—uncertain significance
rs117900466517:7,950,933T/C—uncertain significance
rs145216526817:7,950,939T/C—uncertain significance
rs20061671817:7,950,963C/T—uncertain significance
rs197665321117:7,951,080G/C—uncertain significance
rs14468064117:7,951,153A/G—uncertain significance
rs37279658317:7,951,720A/G—uncertain significance
rs76829022317:7,951,723C/T—uncertain significance
rs77146276317:7,951,752C/T—uncertain significance
rs6173029817:7,951,756G/A—benign
rs76156940317:7,951,772C/G—uncertain significance
rs36855075617:7,951,804T/A—uncertain significance
rs36973917117:7,951,813G/A—uncertain significance
rs53541828117:7,951,851C/T—uncertain significance
rs20170218017:7,951,872G/A—uncertain significance
rs721101317:7,952,759A/Tdownstream gene variant—

Gene information from NCBI Gene. Variant classifications from ClinVar.