rs200065292

This variant is located in the ALOX15B gene.

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ClinVar annotation

Uncertain Significance★☆☆☆

1 submitter

not specified

About ALOX15B

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

View all ALOX15B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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