ALPI

alkaline phosphatase, intestinal

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

Known Variants62 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs146144613	2:233,320,773	G/A	upstream gene variant	—
rs73007641	2:233,320,903	C/G	—	likely benign
rs146003610	2:233,320,929	T/C	—	uncertain significance
rs61736995	2:233,320,967	G/A	—	benign
rs201573533	2:233,321,074	C/T	—	uncertain significance
rs61732026	2:233,321,089	G/T	—	benign
rs778354363	2:233,321,124	C/A	—	uncertain significance
rs145699808	2:233,321,305	C/T	—	uncertain significance
rs61732024	2:233,321,379	C/T	—	likely benign
rs2469607819	2:233,321,395	C/G	—	uncertain significance
rs1454567451	2:233,321,401	C/A	—	uncertain significance
rs61732032	2:233,321,641	C/T	—	benign
rs541317610	2:233,321,669	G/A	—	uncertain significance
rs771730709	2:233,321,679	C/T	—	uncertain significance
rs201841252	2:233,321,714	C/T	—	uncertain significance
rs142255168	2:233,321,733	C/T	—	uncertain significance
rs7559279	2:233,321,739	G/A	—	benign
rs3111341	2:233,321,746	T/A	—	benign
rs773517600	2:233,321,871	G/A	—	uncertain significance
rs755104419	2:233,321,896	A/G	—	uncertain significance
rs144872496	2:233,321,906	G/A	—	likely benign
rs376637511	2:233,321,913	G/A	—	uncertain significance
rs1413529440	2:233,321,961	A/G	—	uncertain significance
rs751904957	2:233,321,976	C/T	—	uncertain significance
rs150355736	2:233,321,977	G/T	—	likely benign
rs115079894	2:233,322,004	C/T	—	benign
rs139371546	2:233,322,286	C/T	—	likely benign
rs146465687	2:233,322,302	A/G	—	uncertain significance
rs141754817	2:233,322,370	C/T	—	likely benign
rs114417218	2:233,322,417	G/A	—	benign
rs2469609929	2:233,322,518	T/C	—	uncertain significance
rs750269899	2:233,322,526	C/T	—	uncertain significance
rs535738085	2:233,322,545	C/T	—	uncertain significance
rs201251145	2:233,322,701	C/T	—	likely benign
rs199565324	2:233,322,720	C/T	—	uncertain significance
rs145002990	2:233,322,721	C/T	—	likely benign
rs147248868	2:233,322,746	C/T	—	uncertain significance
rs756207915	2:233,322,782	A/G	—	uncertain significance
rs371224192	2:233,322,818	C/T	—	uncertain significance
rs775196221	2:233,322,837	T/C	—	uncertain significance
rs2272421	2:233,322,875	T/C	—	benign
rs767122676	2:233,322,929	G/A	—	uncertain significance
rs754753041	2:233,322,938	G/A	—	uncertain significance
rs41265121	2:233,322,958	T/C	—	benign
rs143128875	2:233,322,985	G/A	—	likely benign
rs369397009	2:233,322,991	G/A	—	uncertain significance
rs10195208	2:233,323,000	C/T	—	benign
rs142420344	2:233,323,030	C/T	—	likely benign
rs148298725	2:233,323,057	C/T	—	likely benign
rs772547680	2:233,323,099	G/T	—	likely benign
rs2003780	2:233,323,177	T/C	—	benign
rs140144385	2:233,323,343	G/A	—	likely benign
rs768213111	2:233,323,359	G/T	—	uncertain significance
rs1268288839	2:233,323,384	C/A	—	uncertain significance
rs752854294	2:233,323,396	G/A	—	uncertain significance
rs369043469	2:233,323,575	C/G	—	uncertain significance
rs200403345	2:233,323,584	C/T	—	likely pathogenic
rs146536956	2:233,323,599	G/C	—	uncertain significance
rs145542166	2:233,323,601	G/A	—	likely benign
rs148157889	2:233,323,616	G/C	—	uncertain significance
rs376843697	2:233,323,757	G/A	—	likely benign
rs1024269624	2:233,323,767	T/C	—	uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.