ALPI
alkaline phosphatase, intestinal
Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of bacterial translocation in the gut. [provided by RefSeq, Dec 2014]
Known Variants62 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs146144613 | 2:233,320,773 | G/A | upstream gene variant | — |
| rs73007641 | 2:233,320,903 | C/G | — | likely benign |
| rs146003610 | 2:233,320,929 | T/C | — | uncertain significance |
| rs61736995 | 2:233,320,967 | G/A | — | benign |
| rs201573533 | 2:233,321,074 | C/T | — | uncertain significance |
| rs61732026 | 2:233,321,089 | G/T | — | benign |
| rs778354363 | 2:233,321,124 | C/A | — | uncertain significance |
| rs145699808 | 2:233,321,305 | C/T | — | uncertain significance |
| rs61732024 | 2:233,321,379 | C/T | — | likely benign |
| rs2469607819 | 2:233,321,395 | C/G | — | uncertain significance |
| rs1454567451 | 2:233,321,401 | C/A | — | uncertain significance |
| rs61732032 | 2:233,321,641 | C/T | — | benign |
| rs541317610 | 2:233,321,669 | G/A | — | uncertain significance |
| rs771730709 | 2:233,321,679 | C/T | — | uncertain significance |
| rs201841252 | 2:233,321,714 | C/T | — | uncertain significance |
| rs142255168 | 2:233,321,733 | C/T | — | uncertain significance |
| rs7559279 | 2:233,321,739 | G/A | — | benign |
| rs3111341 | 2:233,321,746 | T/A | — | benign |
| rs773517600 | 2:233,321,871 | G/A | — | uncertain significance |
| rs755104419 | 2:233,321,896 | A/G | — | uncertain significance |
| rs144872496 | 2:233,321,906 | G/A | — | likely benign |
| rs376637511 | 2:233,321,913 | G/A | — | uncertain significance |
| rs1413529440 | 2:233,321,961 | A/G | — | uncertain significance |
| rs751904957 | 2:233,321,976 | C/T | — | uncertain significance |
| rs150355736 | 2:233,321,977 | G/T | — | likely benign |
| rs115079894 | 2:233,322,004 | C/T | — | benign |
| rs139371546 | 2:233,322,286 | C/T | — | likely benign |
| rs146465687 | 2:233,322,302 | A/G | — | uncertain significance |
| rs141754817 | 2:233,322,370 | C/T | — | likely benign |
| rs114417218 | 2:233,322,417 | G/A | — | benign |
| rs2469609929 | 2:233,322,518 | T/C | — | uncertain significance |
| rs750269899 | 2:233,322,526 | C/T | — | uncertain significance |
| rs535738085 | 2:233,322,545 | C/T | — | uncertain significance |
| rs201251145 | 2:233,322,701 | C/T | — | likely benign |
| rs199565324 | 2:233,322,720 | C/T | — | uncertain significance |
| rs145002990 | 2:233,322,721 | C/T | — | likely benign |
| rs147248868 | 2:233,322,746 | C/T | — | uncertain significance |
| rs756207915 | 2:233,322,782 | A/G | — | uncertain significance |
| rs371224192 | 2:233,322,818 | C/T | — | uncertain significance |
| rs775196221 | 2:233,322,837 | T/C | — | uncertain significance |
| rs2272421 | 2:233,322,875 | T/C | — | benign |
| rs767122676 | 2:233,322,929 | G/A | — | uncertain significance |
| rs754753041 | 2:233,322,938 | G/A | — | uncertain significance |
| rs41265121 | 2:233,322,958 | T/C | — | benign |
| rs143128875 | 2:233,322,985 | G/A | — | likely benign |
| rs369397009 | 2:233,322,991 | G/A | — | uncertain significance |
| rs10195208 | 2:233,323,000 | C/T | — | benign |
| rs142420344 | 2:233,323,030 | C/T | — | likely benign |
| rs148298725 | 2:233,323,057 | C/T | — | likely benign |
| rs772547680 | 2:233,323,099 | G/T | — | likely benign |
| rs2003780 | 2:233,323,177 | T/C | — | benign |
| rs140144385 | 2:233,323,343 | G/A | — | likely benign |
| rs768213111 | 2:233,323,359 | G/T | — | uncertain significance |
| rs1268288839 | 2:233,323,384 | C/A | — | uncertain significance |
| rs752854294 | 2:233,323,396 | G/A | — | uncertain significance |
| rs369043469 | 2:233,323,575 | C/G | — | uncertain significance |
| rs200403345 | 2:233,323,584 | C/T | — | likely pathogenic |
| rs146536956 | 2:233,323,599 | G/C | — | uncertain significance |
| rs145542166 | 2:233,323,601 | G/A | — | likely benign |
| rs148157889 | 2:233,323,616 | G/C | — | uncertain significance |
| rs376843697 | 2:233,323,757 | G/A | — | likely benign |
| rs1024269624 | 2:233,323,767 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.