AMMECR1

AMMECR nuclear protein 1

Summary

The exact function of this gene is not known, however, submicroscopic deletion of the X chromosome including this gene, COL4A5, and FACL4 genes, result in a contiguous gene deletion syndrome, the AMME complex (Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Known Variants42 total

rsidPosition (GRCh37)AllelesClassClinVar
rs180715560X:109,441,745G/Tuncertain significance
rs140247782X:109,441,790A/Gbenign
rs765118261X:109,441,793T/Clikely benign
rs145206893X:109,441,819C/Tuncertain significance
rs2522490522X:109,441,852C/Auncertain significance
rs7879171X:109,444,138C/Abenign
rs7879645X:109,444,139A/Tbenign
rs2522493719X:109,444,180A/Tlikely pathogenic
rs1160009207X:109,444,208T/Clikely benign
rs146457392X:109,444,247T/Clikely benign
rs750022919X:109,444,264G/Apathogenic
rs2148162285X:109,444,270G/Auncertain significance
rs2148162290X:109,444,275C/Tlikely pathogenic
rs2148162295X:109,444,278C/Auncertain significance
rs141830389X:109,445,514G/Abenign
rs2522495741X:109,445,707C/Tuncertain significance
rs140856361X:109,445,714T/Cbenign
rs201052711X:109,459,832T/Auncertain significance
rs1057519337X:109,507,771C/Tmissense variantpathogenic
rs2067757957X:109,507,775T/Cuncertain significance
rs1057519338X:109,507,799G/Astop gainedpathogenic
rs765498367X:109,560,871A/Tlikely pathogenic
rs977896524X:109,560,898G/Alikely benign
rs745844977X:109,560,944G/Clikely benign
rs2522638807X:109,560,978G/Auncertain significance
rs2522638827X:109,560,984A/Guncertain significance
rs967455817X:109,560,987A/Cuncertain significance
rs1247385721X:109,560,995G/Auncertain significance
rs199797010X:109,561,017T/Aconflicting classifications of pathogenicity
rs2522639213X:109,561,050C/Alikely benign
rs750347793X:109,561,062C/Guncertain significance
rs1453532929X:109,561,080G/Tuncertain significance
rs2522639532X:109,561,098A/Guncertain significance
rs2522639660X:109,561,122T/Cuncertain significance
rs2068060086X:109,561,173C/Tuncertain significance
rs754418160X:109,561,186C/Guncertain significance
rs915758504X:109,561,214G/Auncertain significance
rs775481785X:109,561,247G/Tconflicting classifications of pathogenicity
rs1452167464X:109,561,277A/Tuncertain significance
rs757962710X:109,561,282G/Alikely benign
rs777610803X:109,561,288A/Glikely benign
rs2883091X:109,684,139G/Cupstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.