ANKH

ANKH inorganic pyrophosphate transport regulator

Summary

This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]

Known Variants416 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1451954355:14,704,920C/Gbenign
rs12381038995:14,704,938C/Tuncertain significance
rs5462349165:14,705,071C/Tuncertain significance
rs1165907505:14,705,080C/Tbenign
rs8860600655:14,705,101C/Tuncertain significance
rs1823000145:14,705,143T/Cbenign
rs7577369995:14,705,177C/Tuncertain significance
rs8860600665:14,705,265A/Guncertain significance
rs8860600675:14,705,272T/Guncertain significance
rs5760510285:14,705,294A/Gconflicting classifications of pathogenicity
rs13734915045:14,705,300T/Auncertain significance
rs9430177195:14,705,326G/Tuncertain significance
rs7471783825:14,705,376G/Auncertain significance
rs8860600685:14,705,394A/Tuncertain significance
rs14238215905:14,705,400A/Guncertain significance
rs9437842055:14,705,406A/Guncertain significance
rs9768961505:14,705,407T/Cuncertain significance
rs8860600695:14,705,408C/Tuncertain significance
rs1412640565:14,705,411G/Cuncertain significance
rs10544391085:14,705,419C/Guncertain significance
rs1455496935:14,705,538A/Gbenign
rs1163625235:14,705,547C/Gbenign
rs1870070815:14,705,581C/Auncertain significance
rs1903966755:14,705,644G/Abenign
rs263075:14,705,665T/Cbenign
rs8860600705:14,705,713C/Guncertain significance
rs12000801535:14,705,727C/Tuncertain significance
rs1431433985:14,705,788G/Abenign
rs797395425:14,705,847G/Abenign
rs9371364725:14,706,244T/Cuncertain significance
rs9010928035:14,706,324A/Guncertain significance
rs1877711985:14,706,348A/Guncertain significance
rs17369464285:14,706,495T/Cuncertain significance
rs9912058565:14,706,529G/Tuncertain significance
rs8860600715:14,706,602A/Cuncertain significance
rs615020425:14,706,634C/Tbenign
rs10368734305:14,706,671T/Guncertain significance
rs785509285:14,706,682T/Gbenign
rs10501304995:14,706,696G/Tuncertain significance
rs1482112905:14,706,793T/Cbenign
rs5635091665:14,706,878A/Gbenign
rs1412098105:14,706,955G/Abenign
rs1507068625:14,707,038G/Tbenign
rs775731325:14,707,055A/Gbenign
rs7769297355:14,707,056A/Guncertain significance
rs1379055025:14,707,062A/Tbenign
rs1473223665:14,707,087A/Gbenign
rs133580745:14,707,124A/Cbenign
rs8860600725:14,707,169C/Guncertain significance
rs1813977725:14,707,203C/Tuncertain significance
rs5284182425:14,707,344A/Guncertain significance
rs279115:14,707,378A/Gbenign
rs766350895:14,707,406A/Gbenign
rs5597630375:14,707,407A/Gbenign
rs8962277175:14,707,554C/Tuncertain significance
rs259925:14,707,600C/Tbenign
rs5638730785:14,707,608A/Tbenign
rs8860600735:14,707,642G/Auncertain significance
rs1410521955:14,707,678A/Gbenign
rs1498151875:14,707,679C/Tbenign
rs5506725205:14,707,690G/Aconflicting classifications of pathogenicity
rs1447896715:14,707,739C/Guncertain significance
rs9176468455:14,707,744C/Auncertain significance
rs8860600745:14,707,747C/Guncertain significance
rs1852335835:14,707,752G/Auncertain significance
rs5394265525:14,707,758C/Tuncertain significance
rs1141643055:14,707,763C/Abenign
rs10064276375:14,707,797C/Guncertain significance
rs790591235:14,707,886G/Abenign
rs3687270705:14,707,920C/Tuncertain significance
rs17369995915:14,707,947A/Cuncertain significance
rs9991384685:14,708,082A/Guncertain significance
rs9335437015:14,708,134T/Cuncertain significance
rs10075995335:14,708,173G/Tuncertain significance
rs1820734495:14,708,332C/Tlikely benign
rs9194143775:14,708,347A/Guncertain significance
rs5638986235:14,708,536G/Auncertain significance
rs1412025035:14,708,592A/Gbenign
rs5696902455:14,708,607C/Gbenign
rs8860600755:14,708,612A/Guncertain significance
rs5359209305:14,708,632G/Cuncertain significance
rs8860600765:14,708,662C/Guncertain significance
rs1436192415:14,708,763C/Gbenign
rs5759306825:14,708,795G/Abenign
rs8860600775:14,708,878C/Guncertain significance
rs9630398385:14,708,913T/Auncertain significance
rs1854887645:14,708,914C/Abenign
rs5371815235:14,709,044C/Abenign
rs5319801605:14,709,063G/Cuncertain significance
rs2014396985:14,709,070C/Tuncertain significance
rs1913343595:14,709,106A/Gbenign
rs1501300255:14,709,187G/Abenign
rs259915:14,709,199T/Cbenign
rs7598908555:14,709,289C/Tuncertain significance
rs5521466955:14,709,318G/Cbenign
rs10173145385:14,709,412A/Guncertain significance
rs1831384645:14,709,492C/Tbenign
rs7753804955:14,709,534G/Auncertain significance
rs9713856705:14,709,552C/Tuncertain significance
rs13290376675:14,709,553G/Auncertain significance

Showing 100 of 416 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.