ANKLE1
ankyrin repeat and LEM domain containing 1
Summary
Enables endonuclease activity. Involved in DNA damage response and protein export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants77 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10419397 | 19:17,391,328 | G/T | — | — |
| rs35586766 | 19:17,392,629 | G/T | — | — |
| rs779039437 | 19:17,392,737 | C/T | — | uncertain significance |
| rs903707304 | 19:17,392,764 | G/C | — | uncertain significance |
| rs566303446 | 19:17,392,775 | C/T | — | uncertain significance |
| rs747832867 | 19:17,392,779 | A/C | — | uncertain significance |
| rs8100241 | 19:17,392,894 | G/A | missense variant | — |
| rs766804036 | 19:17,392,937 | A/G | — | uncertain significance |
| rs1210888730 | 19:17,392,948 | G/A | — | likely benign |
| rs1439112853 | 19:17,393,000 | G/A | — | uncertain significance |
| rs745660318 | 19:17,393,012 | A/G | — | uncertain significance |
| rs1254636473 | 19:17,393,017 | C/G | — | uncertain significance |
| rs767269720 | 19:17,393,476 | C/A | — | uncertain significance |
| rs749176751 | 19:17,393,509 | G/T | — | uncertain significance |
| rs8108174 | 19:17,393,530 | T/A | missense variant | — |
| rs751800505 | 19:17,393,557 | C/T | — | uncertain significance |
| rs765068179 | 19:17,393,728 | G/A | — | uncertain significance |
| rs2513132145 | 19:17,393,730 | G/A | — | uncertain significance |
| rs543764847 | 19:17,393,770 | G/A | — | uncertain significance |
| rs752256530 | 19:17,393,772 | A/G | — | uncertain significance |
| rs762806145 | 19:17,393,778 | G/A | — | uncertain significance |
| rs1332710422 | 19:17,393,796 | G/A | — | uncertain significance |
| rs756766921 | 19:17,393,799 | C/G | — | likely benign |
| rs56069439 | 19:17,393,925 | C/A | regulatory region variant | benign |
| rs59119993 | 19:17,394,051 | C/T | — | benign |
| rs755762252 | 19:17,394,057 | G/C | — | uncertain significance |
| rs2363956 | 19:17,394,124 | T/G | missense variant | — |
| rs201377560 | 19:17,394,138 | G/A | — | uncertain significance |
| rs769921478 | 19:17,394,193 | C/T | — | uncertain significance |
| rs139383004 | 19:17,394,240 | A/C | — | uncertain significance |
| rs767525364 | 19:17,394,247 | T/C | — | uncertain significance |
| rs745388044 | 19:17,394,289 | C/A | — | uncertain significance |
| rs762002502 | 19:17,394,394 | G/A | — | uncertain significance |
| rs377545994 | 19:17,394,457 | T/C | — | uncertain significance |
| rs544403204 | 19:17,394,496 | G/A | — | likely benign |
| rs546961772 | 19:17,394,507 | C/T | — | uncertain significance |
| rs145003500 | 19:17,394,523 | G/A | — | uncertain significance |
| rs778452177 | 19:17,394,571 | C/T | — | uncertain significance |
| rs529290656 | 19:17,394,578 | G/T | — | uncertain significance |
| rs149075471 | 19:17,394,594 | G/A | — | uncertain significance |
| rs769992398 | 19:17,394,606 | G/A | — | uncertain significance |
| rs2513134407 | 19:17,394,625 | G/A | — | uncertain significance |
| rs143128175 | 19:17,394,633 | C/T | — | likely benign |
| rs2513134481 | 19:17,394,652 | C/G | — | uncertain significance |
| rs768659445 | 19:17,394,685 | G/A | — | uncertain significance |
| rs1422395731 | 19:17,394,687 | G/A | — | uncertain significance |
| rs910806903 | 19:17,394,757 | C/T | — | uncertain significance |
| rs767186144 | 19:17,394,943 | G/A | — | uncertain significance |
| rs146387346 | 19:17,394,982 | C/G | — | uncertain significance |
| rs34112069 | 19:17,395,038 | G/A | — | benign |
| rs1218551090 | 19:17,396,252 | C/A | — | uncertain significance |
| rs144326319 | 19:17,396,257 | C/T | — | uncertain significance |
| rs141599824 | 19:17,396,263 | G/A | — | uncertain significance |
| rs146189965 | 19:17,396,272 | C/T | — | uncertain significance |
| rs746989915 | 19:17,396,290 | G/A | — | uncertain significance |
| rs151021327 | 19:17,396,307 | C/T | — | uncertain significance |
| rs551006830 | 19:17,396,308 | G/A | — | likely benign |
| rs2513137141 | 19:17,396,313 | A/G | — | uncertain significance |
| rs1485452664 | 19:17,396,322 | G/A | — | uncertain significance |
| rs149727291 | 19:17,396,343 | C/T | — | uncertain significance |
| rs376579821 | 19:17,396,378 | C/A | — | uncertain significance |
| rs138115996 | 19:17,396,523 | T/G | — | benign |
| rs201853418 | 19:17,396,542 | G/A | — | uncertain significance |
| rs765591299 | 19:17,396,547 | G/A | — | uncertain significance |
| rs775617803 | 19:17,396,548 | G/A | — | uncertain significance |
| rs150249470 | 19:17,396,563 | A/G | — | uncertain significance |
| rs547043530 | 19:17,396,583 | G/A | — | uncertain significance |
| rs146201418 | 19:17,396,584 | C/T | — | uncertain significance |
| rs374646433 | 19:17,396,602 | G/A | — | uncertain significance |
| rs148694019 | 19:17,397,189 | G/C | — | uncertain significance |
| rs200093558 | 19:17,397,198 | C/T | — | likely benign |
| rs539248136 | 19:17,397,258 | G/A | — | uncertain significance |
| rs762351008 | 19:17,397,263 | C/T | — | uncertain significance |
| rs761566717 | 19:17,397,267 | G/A | — | uncertain significance |
| rs192011438 | 19:17,397,289 | C/A | — | uncertain significance |
| rs566365414 | 19:17,397,291 | G/A | — | uncertain significance |
| rs371454519 | 19:17,397,493 | G/T | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.