rs2363956
This is a protein-altering variant in the ANKLE1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
triple-negative breast cancer
▶Research that mentions this SNP (1)
▶A genome-wide association study of breast cancer in women of African ancestryAssociationN=21,921Chen F. et al.(2013)· Human Genetics
Genome-wide association study of breast cancer in 3,153 African American cases and 2,831 controls, with replication in 3,607 cases and 11,330 controls of African ancestry. Two novel susceptibility loci reached statistical significance: rs4322600 at 14q31 (OR=1.18, p=4.3×10⁻⁶) and rs10510333 at 3p26 (OR=1.15, p=1.5×10⁻⁵). These variants represent novel risk loci not previously identified in other populations.
About ANKLE1
Enables endonuclease activity. Involved in DNA damage response and protein export from nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all ANKLE1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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