ARHGAP21

Rho GTPase activating protein 21

Summary

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

Known Variants132 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1127893	10:24,873,369	G/C	—	benign
rs138011350	10:24,873,383	A/T	—	likely benign
rs577578179	10:24,873,396	G/C	—	uncertain significance
rs1309617804	10:24,873,397	G/T	—	uncertain significance
rs146330747	10:24,873,433	C/T	—	likely benign
rs2544851650	10:24,873,438	T/G	—	uncertain significance
rs369268102	10:24,873,460	G/T	—	uncertain significance
rs749840646	10:24,873,474	G/A	—	uncertain significance
rs2544853727	10:24,873,618	C/T	—	uncertain significance
rs372867428	10:24,873,643	G/A	—	uncertain significance
rs774267791	10:24,873,649	G/A	—	uncertain significance
rs377439736	10:24,873,651	T/C	—	uncertain significance
rs1255672155	10:24,873,715	C/A	—	uncertain significance
rs2544855365	10:24,873,739	C/T	—	uncertain significance
rs150046153	10:24,873,784	C/T	—	uncertain significance
rs768755069	10:24,873,823	G/T	—	likely benign
rs566025075	10:24,873,856	C/T	—	uncertain significance
rs190250855	10:24,873,914	C/A	—	likely benign
rs1350804808	10:24,873,964	C/T	—	likely benign
rs772580600	10:24,874,004	T/C	—	likely benign
rs556765739	10:24,874,020	A/G	—	uncertain significance
rs776145004	10:24,874,032	G/A	—	uncertain significance
rs142036127	10:24,874,111	G/A	—	likely benign
rs368102858	10:24,874,189	T/G	—	uncertain significance
rs200596333	10:24,874,221	C/T	—	uncertain significance
rs748737080	10:24,874,256	G/T	—	uncertain significance
rs148825465	10:24,874,310	G/T	—	uncertain significance
rs143603189	10:24,874,327	G/A	—	uncertain significance
rs372262105	10:24,874,343	T/A	—	uncertain significance
rs1396122259	10:24,874,383	G/A	—	uncertain significance
rs745356491	10:24,874,387	C/T	—	uncertain significance
rs563608795	10:24,874,397	C/G	—	uncertain significance
rs529388513	10:24,874,425	C/A	—	uncertain significance
rs376399364	10:24,874,563	G/A	—	uncertain significance
rs2544864854	10:24,874,587	G/C	—	uncertain significance
rs1235870238	10:24,874,759	T/C	—	uncertain significance
rs2544867112	10:24,874,782	G/T	—	uncertain significance
rs370000857	10:24,874,791	T/C	—	uncertain significance
rs200304974	10:24,874,833	C/T	—	uncertain significance
rs751585755	10:24,874,897	A/T	—	uncertain significance
rs201341804	10:24,874,903	T/C	—	uncertain significance
rs749565719	10:24,874,995	A/G	—	uncertain significance
rs142827565	10:24,880,170	G/T	—	likely benign
rs1168433049	10:24,880,208	C/T	—	uncertain significance
rs1458245291	10:24,884,089	C/T	—	uncertain significance
rs537787071	10:24,884,092	T/C	—	uncertain significance
rs3748220	10:24,884,829	A/G	—	benign
rs144834281	10:24,884,955	A/T	—	benign
rs1060499743	10:24,884,959	A/C	missense variant	pathogenic
rs2544976406	10:24,884,969	T/C	—	uncertain significance
rs148593296	10:24,885,708	G/A	—	likely benign
rs111419738	10:24,885,785	C/T	—	benign
rs1023550278	10:24,885,794	T/C	—	uncertain significance
rs2076635439	10:24,886,455	C/A	—	uncertain significance
rs144259265	10:24,886,471	C/T	—	uncertain significance
rs376073062	10:24,889,591	C/T	—	uncertain significance
rs747302284	10:24,889,606	G/A	—	uncertain significance
rs147810945	10:24,889,660	C/G	—	likely benign
rs2545021483	10:24,889,694	T/A	—	uncertain significance
rs200969279	10:24,889,762	G/A	—	uncertain significance
rs957147677	10:24,889,780	T/G	—	uncertain significance
rs200470002	10:24,889,808	C/T	—	uncertain significance
rs372958824	10:24,889,840	C/T	—	uncertain significance
rs1382411579	10:24,890,909	T/C	—	uncertain significance
rs747809170	10:24,890,932	C/T	—	uncertain significance
rs559292729	10:24,890,978	A/T	—	uncertain significance
rs2545034106	10:24,890,998	C/A	—	uncertain significance
rs145052751	10:24,891,013	G/A	—	uncertain significance
rs199839426	10:24,893,264	C/T	—	uncertain significance
rs372303649	10:24,896,497	G/A	—	uncertain significance
rs141406000	10:24,896,519	G/A	—	uncertain significance
rs202179095	10:24,896,697	C/T	—	uncertain significance
rs150817453	10:24,896,824	T/C	—	uncertain significance
rs375040008	10:24,908,481	G/A	—	likely benign
rs370580413	10:24,908,492	G/A	—	uncertain significance
rs367801923	10:24,908,514	G/A	—	likely benign
rs61758699	10:24,908,528	C/T	—	likely benign
rs116419398	10:24,908,529	G/A	—	benign
rs142573508	10:24,908,668	T/C	—	likely benign
rs2545157154	10:24,908,678	A/T	—	uncertain significance
rs781062009	10:24,908,737	G/A	—	uncertain significance
rs749215611	10:24,908,747	C/A	—	uncertain significance
rs140335265	10:24,908,773	G/C	—	conflicting classifications of pathogenicity
rs754596514	10:24,908,821	C/T	—	uncertain significance
rs148074753	10:24,908,880	G/A	—	likely benign
rs1834381829	10:24,908,930	G/A	—	uncertain significance
rs187904291	10:24,908,932	G/A	—	uncertain significance
rs2545159676	10:24,908,947	A/G	—	uncertain significance
rs146902377	10:24,908,950	G/T	—	uncertain significance
rs755805256	10:24,908,952	A/G	—	likely benign
rs141641049	10:24,908,998	C/T	—	benign
rs768759479	10:24,908,999	G/A	—	uncertain significance
rs150869834	10:24,909,106	C/T	—	uncertain significance
rs12765840	10:24,909,135	G/A	—	likely benign
rs771558851	10:24,909,172	T/C	—	uncertain significance
rs761547283	10:24,909,211	C/T	—	uncertain significance
rs565906243	10:24,909,215	T/C	—	uncertain significance
rs778206595	10:24,909,268	T/C	—	uncertain significance
rs534582048	10:24,909,295	T/C	—	likely benign
rs767999340	10:24,909,305	C/T	—	uncertain significance

Showing 100 of 132 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.