ARHGAP28
Rho GTPase activating protein 28
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of stress fiber assembly; regulation of actin filament polymerization; and regulation of small GTPase mediated signal transduction. Located in cell junction and nucleoplasm. Implicated in allergic disease. Biomarker of meningioma. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants38 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs9952482 | 18:6,730,716 | A/C | regulatory region variant | — |
| rs11081265 | 18:6,736,125 | A/G | intron variant | — |
| rs9958628 | 18:6,739,624 | A/T | intron variant | — |
| rs4077790 | 18:6,762,055 | G/C | intron variant | — |
| rs766694829 | 18:6,824,815 | C/G | — | likely benign |
| rs749554860 | 18:6,851,054 | C/T | — | uncertain significance |
| rs147354786 | 18:6,851,069 | G/T | — | uncertain significance |
| rs139451898 | 18:6,851,090 | G/A | — | uncertain significance |
| rs549946935 | 18:6,868,202 | G/C | — | likely benign |
| rs148484875 | 18:6,868,225 | C/T | — | uncertain significance |
| rs2567261 | 18:6,868,925 | T/A | — | — |
| rs2510718963 | 18:6,870,606 | A/G | — | uncertain significance |
| rs2510718967 | 18:6,870,607 | A/G | — | uncertain significance |
| rs760019406 | 18:6,870,662 | G/A | — | uncertain significance |
| rs2510725822 | 18:6,873,460 | C/T | — | uncertain significance |
| rs2510725899 | 18:6,873,500 | T/G | — | uncertain significance |
| rs577318866 | 18:6,873,561 | G/C | — | uncertain significance |
| rs373273554 | 18:6,873,730 | C/G | — | uncertain significance |
| rs2510742357 | 18:6,882,173 | A/G | — | uncertain significance |
| rs2510750151 | 18:6,887,170 | A/G | — | uncertain significance |
| rs774266585 | 18:6,887,207 | C/T | — | uncertain significance |
| rs1243221610 | 18:6,887,225 | G/C | — | uncertain significance |
| rs2510754775 | 18:6,889,957 | C/A | — | uncertain significance |
| rs1206243647 | 18:6,889,995 | A/G | — | uncertain significance |
| rs769114893 | 18:6,890,012 | A/C | — | uncertain significance |
| rs765885648 | 18:6,890,029 | A/G | — | uncertain significance |
| rs201393119 | 18:6,890,130 | C/G | — | likely benign |
| rs144213417 | 18:6,890,475 | C/T | — | uncertain significance |
| rs778345367 | 18:6,890,533 | C/T | — | likely benign |
| rs1442509871 | 18:6,894,858 | G/A | — | uncertain significance |
| rs142301237 | 18:6,894,877 | C/T | — | uncertain significance |
| rs151310799 | 18:6,894,886 | G/A | — | uncertain significance |
| rs536437799 | 18:6,896,511 | C/T | — | uncertain significance |
| rs1379896474 | 18:6,896,613 | A/G | — | uncertain significance |
| rs116232392 | 18:6,908,976 | G/A | — | benign |
| rs370814527 | 18:6,908,981 | A/G | — | uncertain significance |
| rs374455295 | 18:6,912,065 | A/G | — | uncertain significance |
| rs780161676 | 18:6,912,083 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.