ARHGAP45

Rho GTPase activating protein 45

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants30 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7350525119:1,068,095T/Aregulatory region variant—
rs37728375219:1,068,452G/A—uncertain significance
rs75637210419:1,068,472C/T—likely benign
rs75157074019:1,068,651C/T—uncertain significance
rs376465319:1,068,734C/T—benign
rs180128419:1,068,738G/A—benign
rs480750619:1,071,312T/C—benign
rs14502765219:1,073,565C/T—uncertain significance
rs1297453719:1,074,315C/Tintron variant—
rs74915720819:1,074,852G/A—uncertain significance
rs117406443719:1,077,934C/T—uncertain significance
rs7523628819:1,077,947C/T—benign
rs75825046319:1,077,974C/T—likely benign
rs3514070719:1,078,297C/Tintron variant—
rs3553268419:1,078,303T/Cintron variant—
rs204338672619:1,080,113G/A—uncertain significance
rs36824899019:1,081,650C/T—likely benign
rs11588978119:1,081,858G/A—benign
rs1187892019:1,082,266G/Cregulatory region variant—
rs11398625519:1,082,835G/A—benign
rs74554321019:1,082,988T/G—likely benign
rs90443639419:1,083,230G/A—uncertain significance
rs37153269119:1,083,342C/G—uncertain significance
rs3512441319:1,084,314G/C—benign
rs14682739119:1,084,321G/C—likely benign
rs11297563519:1,084,336G/A—likely benign
rs14996069219:1,085,690G/A—benign
rs76035545219:1,085,856G/A—uncertain significance
rs6173493519:1,085,863A/G—benign
rs75916805219:1,085,888A/G—likely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.