rs73505251

This is a regulatory region variant variant in the ARHGAP45 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, dementia, family history of Alzheimer’s disease

Sherva R et al. “African ancestry GWAS of dementia in a large military cohort identifies significant risk loci.” Molecular Psychiatry 28(3):1293-1302 (2023)

Allele A

OR —

p 3.0e-10

N 83,064

Large GWAS

African American or Afro-Caribbean

About ARHGAP45

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of small GTPase mediated signal transduction. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all ARHGAP45 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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