ARHGEF10

Rho guanine nucleotide exchange factor 10

Summary

This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Known Variants658 total

rsidPosition (GRCh37)AllelesClassClinVar
rs111364318:1,791,433T/C—benign
rs7756116858:1,791,590C/A—uncertain significance
rs11563339228:1,791,607C/T—likely benign
rs111364328:1,791,638G/T—benign
rs744153788:1,791,662T/C—benign
rs111364338:1,791,663G/A—benign
rs111364348:1,791,672T/C—benign
rs111364358:1,791,685A/G—benign
rs1498443068:1,792,762A/Gintron variant—
rs177564998:1,805,980T/C—benign
rs112682658:1,806,045G/T—benign
rs1387134158:1,806,116T/C—likely benign
rs2015229498:1,806,117T/A—likely benign
rs25368331998:1,806,138A/G—uncertain significance
rs9173150098:1,806,143G/T—uncertain significance
rs25368338388:1,806,162A/G—uncertain significance
rs9502058508:1,806,164G/C—uncertain significance
rs5476144398:1,806,171G/C—uncertain significance
rs5676075348:1,806,181C/T—likely benign
rs7595035628:1,806,198A/G—uncertain significance
rs7648593518:1,806,209G/T—uncertain significance
rs7750762368:1,806,213C/T—uncertain significance
rs7613123968:1,806,214G/A—likely benign
rs14674386518:1,806,221C/T—uncertain significance
rs7789671908:1,806,226C/G—likely benign
rs1482858588:1,806,227C/T—uncertain significance
rs48759508:1,806,229C/A—benign
rs5590842098:1,806,233G/A—uncertain significance
rs7755589008:1,806,239G/A—uncertain significance
rs7625770538:1,806,248G/A—uncertain significance
rs7680240498:1,806,250T/G—likely benign
rs13740951208:1,806,255G/A—uncertain significance
rs25368365758:1,806,260A/C—uncertain significance
rs1112943168:1,806,268C/T—benign
rs10222007028:1,806,281G/A—uncertain significance
rs7776710418:1,806,287T/G—uncertain significance
rs765221018:1,806,288T/C—likely benign
rs7696929928:1,806,298G/C—likely benign
rs562031068:1,806,333A/G—benign
rs558470358:1,806,334G/A—benign
rs558464958:1,806,353T/G—benign
rs98018218:1,806,372T/C—benign
rs1180168188:1,806,381A/G—benign
rs624775178:1,806,459G/A—benign
rs5393385088:1,806,513C/G——
rs38176928:1,807,855A/G—benign
rs38176938:1,807,864A/G—benign
rs1883123118:1,808,051C/T—benign
rs3677307058:1,808,053G/A—likely benign
rs10417593378:1,808,059C/G—likely benign
rs7635188848:1,808,069A/G—uncertain significance
rs25368738168:1,808,081G/C—uncertain significance
rs18059532658:1,808,092A/T—uncertain significance
rs10292746208:1,808,104G/A—uncertain significance
rs25368745608:1,808,115G/C—uncertain significance
rs12951447348:1,808,119G/C—uncertain significance
rs18059567548:1,808,122C/T—uncertain significance
rs7787616288:1,808,126C/T—uncertain significance
rs1459785108:1,808,127G/A—likely benign
rs5395431078:1,808,154C/T—likely benign
rs5534334088:1,808,155G/A—uncertain significance
rs1398040428:1,808,162C/T—conflicting classifications of pathogenicity
rs1415731108:1,808,163G/A—likely benign
rs18059625698:1,808,173G/C—uncertain significance
rs25368763298:1,808,178C/G—uncertain significance
rs9620532208:1,808,179C/A—uncertain significance
rs7665708858:1,808,183C/T—uncertain significance
rs7534587028:1,808,193C/T—likely benign
rs7526538508:1,808,194G/A—uncertain significance
rs1510436678:1,808,199C/T—likely benign
rs7511344438:1,808,203G/A—conflicting classifications of pathogenicity
rs1448376968:1,808,209G/A—likely benign
rs15852963618:1,808,212G/T—uncertain significance
rs21290750108:1,808,218G/A—uncertain significance
rs1998045398:1,808,221G/T—likely benign
rs7792840708:1,808,229T/C—likely benign
rs25368776038:1,808,234C/T—uncertain significance
rs7608837188:1,808,239G/A—uncertain significance
rs25368778008:1,808,245T/G—uncertain significance
rs7498228:1,808,256G/A—benign
rs1510800258:1,808,270C/T—conflicting classifications of pathogenicity
rs21290751118:1,808,272G/A—uncertain significance
rs7557289088:1,808,275C/A—uncertain significance
rs1409412648:1,808,284C/G—uncertain significance
rs7474763978:1,808,289C/T—likely benign
rs7709345478:1,808,290C/G—uncertain significance
rs1446978258:1,808,295G/T—likely benign
rs7582177848:1,808,301C/T—likely benign
rs5335807478:1,808,302G/A—likely benign
rs10276926288:1,808,314C/T—uncertain significance
rs7669443098:1,808,315C/T—uncertain significance
rs5304708878:1,808,316G/A—likely benign
rs7661866448:1,808,319C/T—likely benign
rs7535081798:1,808,320A/G—uncertain significance
rs18059814338:1,808,325C/G—uncertain significance
rs2014338248:1,808,329G/A—conflicting classifications of pathogenicity
rs3689087458:1,808,334G/A—likely benign
rs1479147248:1,808,343C/T—benign
rs1409474008:1,808,379G/Aintron variant—
rs132750008:1,808,439C/G—benign

Showing 100 of 658 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.

ARHGEF10 — Rho guanine nucleotide exchange factor 10