ARHGEF11
Rho guanine nucleotide exchange factor 11
Summary
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Known Variants87 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs751372327 | 1:156,906,661 | G/A | — | uncertain significance |
| rs150545454 | 1:156,906,718 | A/G | — | uncertain significance |
| rs747398529 | 1:156,906,733 | G/A | — | uncertain significance |
| rs1655519805 | 1:156,906,758 | C/G | — | uncertain significance |
| rs529538605 | 1:156,906,785 | C/T | — | uncertain significance |
| rs1402916016 | 1:156,907,063 | G/A | — | uncertain significance |
| rs767842383 | 1:156,907,078 | G/T | — | uncertain significance |
| rs144152945 | 1:156,907,091 | T/C | — | uncertain significance |
| rs767043672 | 1:156,907,103 | T/C | — | uncertain significance |
| rs201607774 | 1:156,907,126 | C/T | — | uncertain significance |
| rs202063053 | 1:156,907,132 | G/A | — | likely benign |
| rs764554958 | 1:156,907,136 | G/A | — | uncertain significance |
| rs201325770 | 1:156,907,154 | C/A | — | uncertain significance |
| rs370918950 | 1:156,907,171 | T/G | — | uncertain significance |
| rs376999050 | 1:156,907,294 | C/G | — | likely benign |
| rs550659351 | 1:156,909,352 | C/T | — | uncertain significance |
| rs2526550719 | 1:156,909,422 | C/A | — | uncertain significance |
| rs565426652 | 1:156,909,450 | G/T | — | uncertain significance |
| rs567471201 | 1:156,909,496 | G/A | — | uncertain significance |
| rs1200445744 | 1:156,909,564 | C/A | — | uncertain significance |
| rs111558417 | 1:156,909,589 | C/T | — | likely benign |
| rs375668144 | 1:156,909,604 | G/C | — | uncertain significance |
| rs372980428 | 1:156,909,625 | C/T | — | uncertain significance |
| rs532988298 | 1:156,909,672 | C/T | — | uncertain significance |
| rs753571729 | 1:156,910,201 | C/G | — | uncertain significance |
| rs747540330 | 1:156,911,672 | C/T | — | likely benign |
| rs2526702322 | 1:156,911,726 | C/T | — | uncertain significance |
| rs748692640 | 1:156,911,728 | G/T | — | uncertain significance |
| rs372927162 | 1:156,911,752 | C/T | — | uncertain significance |
| rs1277287576 | 1:156,912,539 | T/C | — | uncertain significance |
| rs374600926 | 1:156,913,799 | A/G | — | uncertain significance |
| rs2526865808 | 1:156,914,933 | G/C | — | uncertain significance |
| rs751287525 | 1:156,914,954 | G/A | — | uncertain significance |
| rs200759533 | 1:156,916,729 | C/T | — | uncertain significance |
| rs747246966 | 1:156,917,125 | G/A | — | uncertain significance |
| rs375505289 | 1:156,917,134 | C/T | — | uncertain significance |
| rs1333083907 | 1:156,917,176 | C/T | — | uncertain significance |
| rs761396205 | 1:156,917,607 | C/T | — | likely benign |
| rs776364801 | 1:156,917,708 | G/A | — | uncertain significance |
| rs2526996387 | 1:156,917,716 | G/A | — | uncertain significance |
| rs1361188495 | 1:156,917,745 | G/T | — | uncertain significance |
| rs776704113 | 1:156,917,980 | C/T | — | uncertain significance |
| rs1658532124 | 1:156,918,123 | C/T | — | uncertain significance |
| rs151100430 | 1:156,919,749 | G/C | intron variant | — |
| rs2527103618 | 1:156,921,369 | C/T | — | uncertain significance |
| rs757106673 | 1:156,921,479 | T/C | — | uncertain significance |
| rs151236230 | 1:156,923,224 | T/C | intron variant | — |
| rs891871634 | 1:156,924,693 | G/T | — | uncertain significance |
| rs1226759700 | 1:156,924,695 | G/A | — | uncertain significance |
| rs1390338985 | 1:156,926,268 | C/T | — | uncertain significance |
| rs138989392 | 1:156,928,582 | C/T | — | uncertain significance |
| rs373529045 | 1:156,928,870 | C/A | — | uncertain significance |
| rs578149847 | 1:156,928,914 | C/T | — | uncertain significance |
| rs755424336 | 1:156,928,928 | C/T | — | uncertain significance |
| rs1448019477 | 1:156,931,477 | T/C | — | uncertain significance |
| rs59613921 | 1:156,932,564 | G/A | intron variant | — |
| rs368833707 | 1:156,933,003 | T/C | — | uncertain significance |
| rs145077102 | 1:156,933,019 | G/C | — | uncertain significance |
| rs142012484 | 1:156,933,024 | T/C | — | uncertain significance |
| rs1391083996 | 1:156,933,331 | G/A | — | uncertain significance |
| rs2527466281 | 1:156,933,367 | T/G | — | uncertain significance |
| rs559931812 | 1:156,933,385 | C/T | — | uncertain significance |
| rs183580857 | 1:156,937,787 | C/T | — | likely benign |
| rs200033917 | 1:156,937,916 | A/T | — | uncertain significance |
| rs770624914 | 1:156,939,115 | C/A | — | uncertain significance |
| rs6670563 | 1:156,943,412 | C/T | regulatory region variant | — |
| rs76783162 | 1:156,945,094 | T/A | intron variant | — |
| rs765294400 | 1:156,948,082 | G/A | — | uncertain significance |
| rs777851581 | 1:156,948,100 | G/T | — | uncertain significance |
| rs199615456 | 1:156,954,216 | G/C | — | likely benign |
| rs3819972 | 1:156,954,219 | T/C | — | benign |
| rs6427339 | 1:156,954,267 | C/G | — | — |
| rs6427340 | 1:156,954,384 | T/A | — | — |
| rs117214895 | 1:156,954,556 | C/T | downstream gene variant | — |
| rs150238473 | 1:156,959,915 | C/A | upstream gene variant | — |
| rs4292955 | 1:156,962,191 | G/A | — | — |
| rs883425 | 1:156,969,058 | T/A | intron variant | — |
| rs149515620 | 1:156,969,900 | G/A | intron variant | — |
| rs6686367 | 1:156,981,348 | G/A | intron variant | — |
| rs12065378 | 1:156,983,055 | T/C | — | — |
| rs527887998 | 1:156,987,517 | A/G | — | — |
| rs139270221 | 1:156,993,204 | G/C | intron variant | — |
| rs7550260 | 1:157,001,661 | C/A | intron variant | — |
| rs571605205 | 1:157,009,446 | A/C | — | — |
| rs77710757 | 1:157,010,028 | C/T | intron variant | — |
| rs822585 | 1:157,017,205 | A/T | upstream gene variant | — |
| rs12403413 | 1:157,017,405 | C/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.