rs6427340
This variant is located in the ARHGEF11 gene.
▶Research that mentions this SNP (1)
▶Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese populationAssociationN=990Yutaka Mizuki et al.(2014)· Human Psychopharmacology: Clinical and Experimental
Case-control study of 490 schizophrenia patients and 500 controls in a Japanese population examining 8 SNPs in ARHGEF11. No individual SNP associations were found; however, haplotype analysis revealed significant associations with schizophrenia, including rs6427340-rs6427339 C-C haplotype (P=0.0010) and rs822585-rs6427340-rs6427339 A-C-C haplotype (P=0.0018) as risk factors, with A-C-T showing protective effect (P=0.031).
About ARHGEF11
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
View all ARHGEF11 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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