ARHGEF26
Rho guanine nucleotide exchange factor 26
Summary
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Known Variants66 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs761855865 | 3:153,839,815 | A/G | — | uncertain significance |
| rs563109480 | 3:153,839,837 | G/T | — | uncertain significance |
| rs188383913 | 3:153,839,852 | C/T | — | uncertain significance |
| rs772537950 | 3:153,839,876 | G/A | — | uncertain significance |
| rs1385301187 | 3:153,839,906 | G/C | — | uncertain significance |
| rs552873638 | 3:153,839,908 | C/T | — | uncertain significance |
| rs59508481 | 3:153,839,959 | C/G | missense variant | — |
| rs775191832 | 3:153,839,980 | C/G | — | uncertain significance |
| rs760291288 | 3:153,839,983 | G/A | — | uncertain significance |
| rs1190902053 | 3:153,840,077 | C/T | — | uncertain significance |
| rs1304747726 | 3:153,840,098 | C/T | — | uncertain significance |
| rs767766616 | 3:153,840,130 | C/A | — | uncertain significance |
| rs752216683 | 3:153,840,218 | C/T | — | uncertain significance |
| rs778948077 | 3:153,840,224 | G/C | — | uncertain significance |
| rs775649125 | 3:153,840,226 | A/C | — | uncertain significance |
| rs562101344 | 3:153,840,272 | G/A | — | uncertain significance |
| rs773952535 | 3:153,840,296 | C/T | — | uncertain significance |
| rs2473129483 | 3:153,840,325 | A/C | — | uncertain significance |
| rs747486819 | 3:153,840,334 | C/A | — | uncertain significance |
| rs781076579 | 3:153,840,341 | C/T | — | uncertain significance |
| rs1043794403 | 3:153,840,383 | G/A | — | uncertain significance |
| rs1250061157 | 3:153,840,412 | T/G | — | uncertain significance |
| rs373508464 | 3:153,840,413 | C/T | — | likely benign |
| rs200278056 | 3:153,840,449 | A/T | — | uncertain significance |
| rs949826179 | 3:153,840,506 | C/T | — | uncertain significance |
| rs76130087 | 3:153,840,607 | C/T | — | uncertain significance |
| rs764497151 | 3:153,840,767 | G/T | — | uncertain significance |
| rs745378067 | 3:153,840,806 | C/G | — | uncertain significance |
| rs371069494 | 3:153,840,833 | A/G | — | uncertain significance |
| rs765675256 | 3:153,840,839 | A/C | — | uncertain significance |
| rs1727889 | 3:153,843,667 | T/G | regulatory region variant | — |
| rs764898548 | 3:153,847,414 | C/G | — | uncertain significance |
| rs1249642392 | 3:153,847,455 | A/G | — | uncertain significance |
| rs772243711 | 3:153,847,491 | T/C | — | uncertain significance |
| rs768038426 | 3:153,847,497 | C/G | — | uncertain significance |
| rs747148864 | 3:153,847,499 | A/T | — | uncertain significance |
| rs2473205921 | 3:153,870,598 | T/C | — | uncertain significance |
| rs1720101998 | 3:153,870,615 | T/A | — | uncertain significance |
| rs768494131 | 3:153,870,708 | G/A | — | uncertain significance |
| rs357488 | 3:153,885,006 | A/G | intron variant | — |
| rs3906747 | 3:153,887,179 | T/C | intron variant | — |
| rs357468 | 3:153,898,560 | A/G | intron variant | — |
| rs357466 | 3:153,902,868 | A/G | intron variant | — |
| rs561487483 | 3:153,905,517 | A/T | — | uncertain significance |
| rs543945754 | 3:153,905,536 | T/C | — | uncertain significance |
| rs754708272 | 3:153,905,608 | G/A | — | uncertain significance |
| rs401162 | 3:153,905,988 | T/A | intron variant | — |
| rs1299288301 | 3:153,909,145 | C/G | — | uncertain significance |
| rs2473313426 | 3:153,909,148 | A/T | — | uncertain significance |
| rs918886280 | 3:153,909,202 | A/T | — | uncertain significance |
| rs754682447 | 3:153,912,464 | C/T | — | uncertain significance |
| rs778320272 | 3:153,912,482 | A/G | — | uncertain significance |
| rs374617836 | 3:153,935,686 | G/A | — | uncertain significance |
| rs1284081558 | 3:153,935,742 | A/G | — | uncertain significance |
| rs357494 | 3:153,937,753 | G/A | intron variant | — |
| rs775562063 | 3:153,943,734 | G/T | — | uncertain significance |
| rs374902966 | 3:153,943,749 | A/C | — | uncertain significance |
| rs2473418352 | 3:153,943,792 | A/C | — | uncertain significance |
| rs1716462643 | 3:153,943,796 | A/G | — | uncertain significance |
| rs9816553 | 3:153,957,050 | G/A | — | — |
| rs768573483 | 3:153,958,365 | C/T | — | uncertain significance |
| rs551411802 | 3:153,970,909 | G/A | — | uncertain significance |
| rs756726624 | 3:153,970,913 | G/A | — | uncertain significance |
| rs769955658 | 3:153,970,948 | G/A | — | uncertain significance |
| rs372579004 | 3:153,972,587 | T/G | — | uncertain significance |
| rs773704441 | 3:153,973,144 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.