ARL3

ARF like GTPase 3

Summary

Enables GDP binding activity; GTP binding activity; and microtubule binding activity. Involved in several processes, including cilium assembly; protein localization to cilium; and small GTPase-mediated signal transduction. Acts upstream of or within post-Golgi vesicle-mediated transport. Located in several cellular components, including microtubule cytoskeleton; midbody; and photoreceptor connecting cilium. Implicated in Joubert syndrome and retinitis pigmentosa 83. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants119 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37654847610:104,436,665C/T—uncertain significance
rs133660522010:104,436,678G/A—uncertain significance
rs213599384210:104,436,682A/G—uncertain significance
rs138118694910:104,436,688T/A—uncertain significance
rs120472855110:104,436,690C/T—uncertain significance
rs14163101810:104,436,691A/G—uncertain significance
rs76805450710:104,436,692T/C—uncertain significance
rs77433967610:104,436,705G/A—likely benign
rs124203084510:104,436,711T/G—likely benign
rs249294129710:104,436,715C/T—likely benign
rs206418107810:104,445,562T/C—likely benign
rs144110353010:104,445,567T/C—uncertain significance
rs249295096210:104,445,572C/T—uncertain significance
rs37436528810:104,445,578C/T—uncertain significance
rs54706731910:104,445,579G/A—likely benign
rs18219485010:104,445,581C/T—uncertain significance
rs144646275110:104,445,592A/C—uncertain significance
rs77833246310:104,445,602A/C—uncertain significance
rs147585772310:104,445,605A/C—uncertain significance
rs37601899210:104,445,622C/T—uncertain significance
rs117772049210:104,445,623G/A—uncertain significance
rs77770533410:104,445,626C/T—uncertain significance
rs74674371910:104,445,627G/A—likely benign
rs77078266310:104,445,628C/T—conflicting classifications of pathogenicity
rs77690185810:104,445,629G/A—pathogenic
rs76988835410:104,445,639C/T—likely benign
rs249295111910:104,445,644T/A—uncertain significance
rs36886898410:104,445,655G/A—uncertain significance
rs206418181710:104,445,658A/G—uncertain significance
rs20177138610:104,445,670G/A—likely benign
rs76782841310:104,445,671G/A—uncertain significance
rs142095289010:104,445,681G/A—likely benign
rs249295122810:104,445,695T/C—uncertain significance
rs75209520210:104,445,707T/C—uncertain significance
rs142839315810:104,445,719C/T—uncertain significance
rs55136632410:104,445,721C/A—conflicting classifications of pathogenicity
rs249295128310:104,445,722A/G—uncertain significance
rs249295128710:104,445,723A/G—likely benign
rs206418235910:104,445,738C/T—likely benign
rs206418237410:104,445,746A/C—uncertain significance
rs77049199310:104,445,750C/T—likely benign
rs136182695110:104,445,760T/C—uncertain significance
rs121058710210:104,445,768G/A—likely benign
rs96609109310:104,445,775G/C—likely benign
rs1119136810:104,449,444C/Tintron variant—
rs75710343310:104,449,634A/G—likely benign
rs206420774610:104,449,635A/C—likely benign
rs78121275610:104,449,639G/T—likely benign
rs206420782310:104,449,654C/T—uncertain significance
rs57674129710:104,449,656C/T—likely benign
rs37050546810:104,449,657G/A—conflicting classifications of pathogenicity
rs159012222910:104,449,669C/A—pathogenic
rs20172717110:104,449,677G/T—uncertain significance
rs213600037910:104,449,686G/A—likely benign
rs133461059610:104,449,688C/T—uncertain significance
rs13867021810:104,449,689G/A—likely benign
rs156473044010:104,449,696T/C—conflicting classifications of pathogenicity
rs37421962010:104,449,703A/T—uncertain significance
rs36842321710:104,459,112G/A—likely benign
rs206426600710:104,459,124A/T—uncertain significance
rs75520864210:104,459,138C/T—uncertain significance
rs20145157310:104,459,139G/A—likely benign
rs206426609510:104,459,153A/C—uncertain significance
rs213600527110:104,459,154A/G—likely benign
rs77219394310:104,459,172G/A—likely benign
rs14288812610:104,459,179C/T—uncertain significance
rs213600529710:104,459,183G/A—uncertain significance
rs213600530010:104,459,186C/T—uncertain significance
rs206426632410:104,459,194T/A—uncertain significance
rs249296927010:104,459,195C/T—uncertain significance
rs74760363610:104,459,199T/C—likely benign
rs14826044510:104,459,202A/G—likely benign
rs213600532710:104,459,225G/A—uncertain significance
rs14741203110:104,459,228C/T—uncertain significance
rs115943186310:104,459,230C/T—uncertain significance
rs249296933910:104,459,234T/A—uncertain significance
rs76367892210:104,459,239T/C—uncertain significance
rs249296935310:104,459,241G/T—uncertain significance
rs213600534410:104,459,248T/C—uncertain significance
rs213600534610:104,459,249G/A—uncertain significance
rs213600535110:104,459,256G/A—likely benign
rs249296937210:104,459,264A/C—likely benign
rs1276990610:104,463,301C/A——
rs19294791510:104,465,086G/A—likely benign
rs77273722210:104,465,104T/C—uncertain significance
rs76012190910:104,465,106T/C—likely benign
rs249297731710:104,465,134G/C—uncertain significance
rs13964545510:104,465,136T/C—benign
rs213600869710:104,465,151A/C—likely benign
rs14474339310:104,465,153G/A—uncertain significance
rs249297737210:104,465,157G/A—likely benign
rs206430410210:104,465,159T/C—conflicting classifications of pathogenicity
rs213600870810:104,465,164C/A—uncertain significance
rs124945195410:104,465,168C/T—uncertain significance
rs206430415210:104,465,173T/C—uncertain significance
rs75861049810:104,465,178G/A—likely benign
rs213600871610:104,465,180C/T—uncertain significance
rs206430422810:104,465,182A/C—uncertain significance
rs76066968010:104,465,186G/A—uncertain significance
rs120307263010:104,465,205G/A—likely benign

Showing 100 of 119 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.