ASAP1

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

Summary

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Known Variants45 total

rsidPosition (GRCh37)AllelesClassClinVar
rs25401970608:131,066,996A/Guncertain significance
rs25401973638:131,067,042T/Cuncertain significance
rs7541984198:131,072,826G/Auncertain significance
rs1406744588:131,072,855C/Tlikely benign
rs7770293518:131,072,881C/Tuncertain significance
rs15649138778:131,072,913G/Cuncertain significance
rs25402406468:131,072,949G/Auncertain significance
rs2007640588:131,073,150G/Auncertain significance
rs25402436968:131,073,203G/Alikely benign
rs13834375448:131,092,171A/Cuncertain significance
rs69840458:131,092,413T/Cregulatory region variant
rs7725478298:131,104,339C/Tuncertain significance
rs20975068298:131,104,360G/Tuncertain significance
rs7736102728:131,104,362G/Auncertain significance
rs1474010498:131,124,378G/Auncertain significance
rs9443109378:131,124,379T/Clikely benign
rs7661984668:131,124,492T/Cuncertain significance
rs5394507038:131,124,504G/Auncertain significance
rs1468861168:131,128,940G/Cuncertain significance
rs1510888088:131,130,429C/Tuncertain significance
rs1410179488:131,130,462C/Tuncertain significance
rs7625601418:131,130,781T/Cuncertain significance
rs1502215828:131,130,788G/Tuncertain significance
rs13382121968:131,130,880T/Cuncertain significance
rs20975776158:131,140,256C/Tuncertain significance
rs20975776358:131,140,259T/Cuncertain significance
rs25409656318:131,165,007C/Tuncertain significance
rs1131634158:131,181,271C/Tbenign
rs117746598:131,190,336C/G
rs727223658:131,190,914G/C
rs2002683568:131,193,022C/Tuncertain significance
rs18143025868:131,193,031T/Cuncertain significance
rs1512817258:131,226,807T/Auncertain significance
rs10172818:131,247,213G/T
rs586826358:131,270,740T/Gintron variant
rs47337818:131,296,767A/Cregulatory region variant
rs1397957688:131,314,036T/Aintron variant
rs30578:131,329,837C/G
rs64708118:131,338,933G/Tintron variant
rs798947498:131,347,508T/Cintron variant
rs792132238:131,374,611G/Cregulatory region variant
rs1114427358:131,375,252C/Tintron variant
rs5595258698:131,386,737G/T
rs5714448138:131,387,296C/T
rs100872878:131,407,954A/G

Gene information from NCBI Gene. Variant classifications from ClinVar.