AURKA
aurora kinase A
Summary
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6024836 | 20:54,944,068 | G/T | — | — |
| rs8173 | 20:54,944,791 | C/G | downstream gene variant | — |
| rs34361943 | 20:54,945,211 | T/G | — | benign |
| rs2146120963 | 20:54,945,341 | C/A | — | uncertain significance |
| rs748492974 | 20:54,945,386 | G/A | — | uncertain significance |
| rs1455074519 | 20:54,945,388 | G/T | — | likely pathogenic |
| rs1046125726 | 20:54,945,602 | A/G | — | uncertain significance |
| rs10485805 | 20:54,945,783 | A/G | downstream gene variant | — |
| rs911160 | 20:54,957,563 | G/C | intron variant | — |
| rs2298016 | 20:54,959,296 | G/T | intron variant | — |
| rs142801740 | 20:54,959,386 | T/C | — | likely benign |
| rs1986344818 | 20:54,961,318 | G/A | — | uncertain significance |
| rs2230743 | 20:54,961,321 | G/A | — | likely benign |
| rs769911074 | 20:54,961,410 | C/G | — | uncertain significance |
| rs767515238 | 20:54,961,423 | G/A | — | likely benign |
| rs373634582 | 20:54,961,443 | C/G | — | uncertain significance |
| rs1047972 | 20:54,961,463 | T/C | missense variant | benign |
| rs2273535 | 20:54,961,541 | A/G | missense variant | benign |
| rs2064863 | 20:54,962,772 | T/G | upstream gene variant | — |
| rs142322743 | 20:54,963,233 | G/A | — | benign |
| rs745894289 | 20:54,963,246 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.