rs8173
This is a downstream gene variant variant in the AURKA gene.
▶Research that mentions this SNP (2)
▶Association of theAURKAandAURKCgene polymorphisms with an increased risk of gastric cancerAssociationN=439Aner Mesic et al.(2016)· IUBMB Life
Case-control study investigating AURKA gene polymorphisms and CNS tumor susceptibility in 191 Chinese children with CNS tumors and 248 controls. AURKA rs8173 G>C exhibited a protective effect against CNS tumor risk (GC/CC vs. GG: adjusted OR=0.68, 95% CI=0.46-0.998, p=0.049). Carriers with three protective genotypes showed a 0.55-fold reduction in CNS tumor risk (adjusted OR=0.55, 95% CI=0.31-0.98, p=0.044).
▶Bladder cancer SNP panel predicts susceptibility and survivalAssociationN=2,023Angeline S. Andrew et al.(2009)· Human Genetics
A population-based case-control study of 832 bladder cancer cases and 1,191 controls examining SNPs in cancer-regulatory pathways identified increased risk associated with MTHFD2 (OR 1.7, 95% CI 1.3-2.3), TEP1 (OR 1.8, 95% CI 1.2-2.6), and decreased risk with IL8RB (OR 0.6, 95% CI 0.5-0.9). Survival analysis found shorter survival with CASP9 variants (HR 1.8, 95% CI 1.1-3.0) and longer survival with EPHX1 variants (HR 0.4, 95% CI 0.2-0.8). Multi-SNP combinations in metabolism, DNA repair, telomerase, and apoptosis pathways were also predictive of bladder cancer risk and prognosis.
About AURKA
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
View all AURKA variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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