BIK
BCL2 interacting killer
Summary
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs4988364 | 22:43,505,444 | C/T | — | — |
| rs926328 | 22:43,506,265 | T/C | — | — |
| rs1883264 | 22:43,509,846 | G/C | intron variant | — |
| rs11704452 | 22:43,511,868 | T/G | intron variant | — |
| rs4988389 | 22:43,515,339 | T/G | regulatory region variant | — |
| rs4988398 | 22:43,516,726 | G/A | intron variant | — |
| rs742134 | 22:43,518,275 | A/C | — | — |
| rs765529233 | 22:43,520,064 | G/C | — | likely benign |
| rs369306278 | 22:43,520,102 | C/T | — | likely benign |
| rs748570562 | 22:43,520,113 | G/T | — | uncertain significance |
| rs188271449 | 22:43,520,152 | A/C | — | uncertain significance |
| rs764991112 | 22:43,520,153 | T/C | — | uncertain significance |
| rs756641544 | 22:43,523,707 | G/A | — | uncertain significance |
| rs150558820 | 22:43,523,765 | C/A | — | uncertain significance |
| rs2235316 | 22:43,523,991 | C/T | — | — |
| rs777319617 | 22:43,524,531 | C/G | — | uncertain significance |
| rs565578995 | 22:43,524,536 | G/A | — | uncertain significance |
| rs2518095518 | 22:43,524,537 | A/G | — | likely benign |
| rs41304435 | 22:43,524,582 | T/C | — | uncertain significance |
| rs368572843 | 22:43,524,621 | C/T | — | uncertain significance |
| rs909366591 | 22:43,525,009 | G/A | — | — |
| rs532663391 | 22:43,525,228 | G/A | — | uncertain significance |
| rs145876995 | 22:43,525,256 | T/C | — | uncertain significance |
| rs760336241 | 22:43,525,273 | C/G | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.