BRK1

BRICK1 subunit of SCAR/WAVE actin nucleating complex

Summary

Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants75 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1131531203:10,156,398G/A—benign
rs1125091863:10,156,533A/G—benign
rs1395380043:10,156,783G/C—benign
rs678524633:10,157,205G/C—benign
rs76456673:10,157,337C/A—benign
rs76457593:10,157,368C/T—benign
rs285322063:10,157,598C/A—benign
rs170324143:10,158,302C/G—benign
rs414640503:10,158,393A/G—benign
rs5741317933:10,158,457G/T——
rs1457532793:10,159,796G/A—benign
rs601726873:10,159,798A/G—benign
rs11776745193:10,159,936C/A—benign
rs731174813:10,160,132C/T—benign
rs67761763:10,160,259T/C—benign
rs9020584383:10,160,827C/A—benign
rs8119073:10,160,891A/G—benign
rs1116136233:10,161,115C/G—benign
rs98119083:10,161,405G/T—benign
rs676264683:10,161,518C/A—benign
rs731174893:10,162,873G/T—benign
rs1485663813:10,163,243G/T——
rs1119981603:10,163,438C/T—benign
rs1121803223:10,163,659C/T—benign
rs1133785283:10,163,725C/A—benign
rs1138484143:10,163,733T/C—benign
rs1921377413:10,163,793G/A—benign
rs1833950023:10,163,794T/G—benign
rs572688643:10,164,233C/A—benign
rs622455503:10,164,280T/C—benign
rs588624813:10,164,308G/A—benign
rs590745483:10,164,347G/C—benign
rs37742083:10,164,722T/G—benign
rs67837053:10,164,783A/G—benign
rs117106073:10,165,212C/T—benign
rs134338863:10,165,264G/A—benign
rs127148513:10,165,301A/G—benign
rs766474863:10,165,318T/C—benign
rs1813308203:10,165,319T/C—benign
rs716230833:10,165,322G/C—benign
rs130855053:10,165,325A/G—benign
rs127148523:10,165,332A/C—benign
rs1491288213:10,165,342T/A—benign
rs1909106993:10,165,565A/G—benign
rs1118068093:10,165,698T/C—benign
rs680132393:10,165,711G/T—benign
rs681216413:10,165,845T/A—benign
rs1112840323:10,165,909C/T—benign
rs1117088203:10,165,939C/T—benign
rs673428183:10,166,406G/A—benign
rs731197683:10,166,419T/C—benign
rs665146273:10,166,632A/C—benign
rs1115608583:10,166,845G/A—benign
rs1132685313:10,167,069A/G—benign
rs170324263:10,167,112G/A—benign
rs676679573:10,167,264G/C—benign
rs560876003:10,167,576T/A—benign
rs1484068923:10,167,671A/G—benign
rs562747013:10,167,790G/A—benign
rs67859763:10,168,647T/C—benign
rs64421543:10,168,785T/C—benign
rs67975363:10,168,802A/G—benign
rs38943203:10,168,864A/C—benign
rs38943213:10,168,892T/G—benign
rs772673963:10,168,905C/T—benign
rs38943223:10,168,965G/A—benign
rs38943233:10,168,967G/A—benign
rs1434228623:10,169,011C/T—benign
rs38943243:10,169,114G/A—benign
rs674394403:10,169,503C/T—benign
rs583962573:10,169,556A/T—benign
rs591328263:10,169,725G/A—benign
rs582234823:10,169,746G/C—benign
rs170324403:10,169,819G/T—benign
rs608976913:10,170,029C/T—benign

Gene information from NCBI Gene. Variant classifications from ClinVar.