rs9811908
This variant is located in the BRK1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
urinary bladder cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.33
p 2.0e-15
N 627,011
Major Consortium StudyLarge GWAS
multi-ancestry
kidney cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.43
p 5.0e-15
N 121,493
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
▶ClinVar annotation
Benign★☆☆☆
1 submitterAbout BRK1
Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Jul 2025]
View all BRK1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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