BRMS1
BRMS1 transcriptional repressor and anoikis regulator
Summary
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Known Variants28 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs370037659 | 11:66,105,148 | C/T | — | benign |
| rs548463046 | 11:66,105,149 | G/A | — | likely benign |
| rs375487769 | 11:66,105,170 | G/A | — | likely benign |
| rs1328380714 | 11:66,105,203 | A/G | — | likely benign |
| rs779744968 | 11:66,105,242 | G/A | — | uncertain significance |
| rs539150884 | 11:66,105,272 | C/T | — | likely benign |
| rs1854977392 | 11:66,105,721 | T/A | — | uncertain significance |
| rs1415586092 | 11:66,105,737 | G/A | — | uncertain significance |
| rs149983593 | 11:66,105,744 | C/T | — | uncertain significance |
| rs544134195 | 11:66,106,196 | T/C | — | uncertain significance |
| rs1212409210 | 11:66,106,238 | A/G | — | uncertain significance |
| rs756789967 | 11:66,107,661 | C/T | — | uncertain significance |
| rs141305456 | 11:66,107,673 | C/T | — | uncertain significance |
| rs200297342 | 11:66,108,247 | G/A | — | uncertain significance |
| rs17850564 | 11:66,108,255 | G/A | — | benign |
| rs200013073 | 11:66,108,268 | C/T | — | uncertain significance |
| rs755492023 | 11:66,108,308 | C/G | — | uncertain significance |
| rs186635131 | 11:66,108,503 | A/G | — | uncertain significance |
| rs776182648 | 11:66,108,509 | T/C | — | uncertain significance |
| rs374007540 | 11:66,108,718 | C/A | — | uncertain significance |
| rs767755816 | 11:66,108,752 | C/T | missense variant | — |
| rs367854116 | 11:66,108,770 | G/A | — | uncertain significance |
| rs777193514 | 11:66,109,019 | G/A | — | uncertain significance |
| rs759834920 | 11:66,109,024 | C/G | — | uncertain significance |
| rs1429183916 | 11:66,109,047 | C/T | — | uncertain significance |
| rs1272276930 | 11:66,109,076 | T/C | — | uncertain significance |
| rs550292191 | 11:66,109,658 | C/A | — | uncertain significance |
| rs142767365 | 11:66,109,662 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.