C1GALT1

core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Summary

The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]

Known Variants36 total

rsidPosition (GRCh37)AllelesClassClinVar
rs556373967:7,217,867G/Ccoding sequence variant
rs102793767:7,233,913T/G
rs1431105927:7,236,131A/Tintron variant
rs117711937:7,238,107A/C
rs44769147:7,239,555C/Tintron variant
rs9714817:7,243,033C/Gintron variant
rs28817557:7,256,439C/A
rs127025957:7,259,270C/Aintron variant
rs102590857:7,268,431C/G
rs77879427:7,270,012A/Tintron variant
rs10088987:7,273,559G/Tintron variant
rs7560774887:7,274,003T/Cuncertain significance
rs7738665517:7,274,011C/Auncertain significance
rs412826857:7,274,054T/Gbenign
rs7644346667:7,274,069A/Guncertain significance
rs41411007:7,276,954G/T
rs7610046587:7,277,978A/Cuncertain significance
rs7633836927:7,277,993A/Guncertain significance
rs14641210657:7,278,006G/Tuncertain significance
rs25345483987:7,278,016A/Cuncertain significance
rs21282510577:7,278,062G/Auncertain significance
rs17834683787:7,278,072C/Guncertain significance
rs7739166217:7,278,131G/Cuncertain significance
rs7662239177:7,278,180C/Tuncertain significance
rs3770758477:7,278,192T/Cuncertain significance
rs14081018787:7,278,369G/Auncertain significance
rs7813548737:7,278,378T/Cuncertain significance
rs1449735617:7,278,392C/Tlikely benign
rs1864808407:7,278,416A/Guncertain significance
rs617448157:7,278,447T/Alikely benign
rs3692147547:7,278,484C/Guncertain significance
rs1414546507:7,278,506C/Tuncertain significance
rs3740687317:7,283,284C/Guncertain significance
rs7778447607:7,283,291G/Auncertain significance
rs7494528927:7,283,335A/Guncertain significance
rs10477637:7,283,569G/A3 prime UTR variant

Gene information from NCBI Gene. Variant classifications from ClinVar.